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1、,MARKET RESEARCH REPORT,INFECTIOUS DISEASE TREATMENTS:,GLOBAL MARKETS,PHM061A,Peggy Lehr,Project Analyst,BCC Research,35 Walnut Street,Wellesley,MA 02481,Phone:866-285-7215(sales),Web Address:,E-mail:,ISBN:1-59623-590-X,ii,PHM061A Infectious Disease Treatments:Global Markets,TABLE OF CONTENTS,ABOUT
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11、ts:Global Markets,TABLE OF CONTENTS,CHAPTER ONE:INTRODUCTION.1STUDY GOALS AND OBJECTIVES.1REASONS FOR DOING THE STUDY.1SCOPE OF REPORT.2INTENDED AUDIENCE.2METHODOLOGIES AND INFORMATION SOURCES.2ANALYST CREDENTIALS.2RELATED BCC REPORTS.2BCC ONLINE SERVICES.3DISCLAIMER.3CHAPTER TWO:SUMMARY.4SUMMARY.4S
12、UMMARY TABLE GLOBAL MARKET FOR INFECTIOUS DISEASETREATMENTS,THROUGH 2014($BILLIONS).5SUMMARY FIGURE GLOBAL MARKET FOR INFECTIOUS DISEASETREATMENTS,2008-2014($BILLIONS).5CHAPTER THREE:OVERVIEW.6,TABLE 1 SELECTED MAJOR INFECTIOUS DISEASES,WORLDWIDE,2006(NUMBER OF CASES,ANNUALLY).6TABLE 1(CONTINUED).7H
13、ISTORICAL IMPACT OF INFECTIOUS DISEASES.7LINKING INFECTIOUS DISEASE TO CANCER.8TRANSMISSION OF INFECTIOUS DISEASES.8TREATMENTS FOR INFECTIOUS DISEASES.8PREVENTION.8VACCINATION.9FIGURE 1 PERCENT OF PREVENTABLE CHILDHOOD DEATHS,WITH VACCINATION,2002(%).9FIGURE 1(CONTINUED).10TABLE 2 MAJOR MANUFACTURER
14、S OF VACCINES FOR,INFECTIOUS DISEASES,2008.10,TABLE 3 ESTIMATED VACCINE SALES FOR INFECTIOUS,DISEASES,BY MANUFACTURER,2008(%/$MILLIONS).11,TABLE 4 PROJECTED SALES OF VACCINES TO TREATINFECTIOUS DISEASES WORLDWIDE,THROUGH 2014($,BILLIONS).12TABLE 5 SELECTED TREATMENT MODALITIES,BY DISEASE ANDTYPE OF
15、PRODUCT.12,MONITORING AND SURVEILLANCE.13,Copyright BCC Research,Wellesley,MA USA,Web:,iv,PHM061A Infectious Disease Treatments:Global Markets,TABLE OF CONTENTS,CURRENT IMPACT OF INFECTIOUS DISEASES.13TABLE 6 TOP 10 CAUSES OF DEATH,BY INCOME GROUP,2004(%).13TABLE 6(CONTINUED).14,ANTIBIOTIC-RESISTANT
16、 ORGANISMS.14IMPLICATIONS OF CLIMATE-CHANGE ON INFECTIOUSDISEASES.14KEY DRIVERS OF INFECTIOUS DISEASE PRODUCT MARKET.15KEY OBSTACLES IN THE INFECTIOUS DISEASE PRODUCT,MARKET.15OPPORTUNITIES TO FIGHT INFECTIOUS DISEASES.16OPPORTUNITIES TO FIGHT(CONTINUED).17CHAPTER FOUR:THE GLOBAL STATE OF INFECTIOUS
17、 DISEASE,CONTROL AND TREATMENT.18FACTORS IN THE EMERGENCE OF INFECTIONS.18HUMAN DEMOGRAPHICS AND BEHAVIOR.18TECHNOLOGY.18ECONOMIC DEVELOPMENT AND LAND USE.19INTERNATIONAL TRAVEL.19MICROBIAL ADAPTATION.19TABLE 7 HISTORY OF ANTIBIOTIC DISCOVERY AND APPROVAL.20,PUBLIC HEALTH MEASURES.20GLOBAL IMPLICATI
18、ONS OF INFECTIOUS DISEASES.20REGIONAL TRENDS.21,Sub-Saharan Africa.21Asia and the Pacific.21The Former Soviet Union and Eastern Europe.21Latin America.21Middle East and North Africa.21Western Europe.22GLOBAL ECONOMIC,SOCIAL,AND POLITICAL IMPACT.22ECONOMIC COSTS.22SOCIAL COSTS.23POLITICAL IMPACT.23IM
19、PLICATIONS OF INFECTIOUS DISEASE IN THE U.S.23HIV/AIDS.23HEPATITIS C.24TUBERCULOSIS.24INFLUENZA.24ANTIBIOTIC-RESISTANT PATHOGENS.24FOOD-BORNE ILLNESSES.24,Copyright BCC Research,Wellesley,MA USA,Web:,v,PHM061A Infectious Disease Treatments:Global Markets,TABLE OF CONTENTS,INFECTIOUS DISEASES ACQUIRE
20、D OUTSIDE OF THE U.S.25EMERGING INFECTIOUS DISEASES.25EMERGING BACTERIAL INFECTIOUS DISEASES.25EMERGING VIRAL INFECTIOUS DISEASES.25Metapneumoviruses.26HenipavirusNipah,Hendra.26PRION DISEASE.26CREATING TREATMENTS FOR INFECTIOUS DISEASE.27CREATING DRUG TREATMENTS.27TABLE 8 PROCESS OF CREATING DRUG T
21、REATMENTS.27TABLE 8(CONTINUED).28,CREATING VACCINES.29Creating Vaccines(Continued).30TABLE 9 TOP FIVE VACCINE-PRODUCING COMPANIES,2009.31,ACQUISITIONS AMONG MANUFACTURERS OF,INFECTIOUS DISEASE PRODUCTS.31TABLE 10 SELECTED ACQUISITIONS AMONG INFECTIOUS,DISEASE DRUG AND VACCINE MANUFACTURERS,2006-2010
22、.31TABLE 10(CONTINUED).32CHAPTER FIVE:BACTERIAL INFECTIOUS DISEASES.33,TABLE 11 SELECTED BACTERIAL INFECTIOUS DISEASES AND,THE NUMBER OF CASES IN HUMANS.33TABLE 11(CONTINUED).34TABLE 12 PROJECTED MARKET FOR ANTIBACTERIAL,TREATMENTS THROUGH 2014($MILLIONS).34THE GLOBAL ANTIBACTERIAL DRUG MARKET.35TRE
23、ATMENTS.35,FIGURE 2 LEADING MANUFACTURERS OF ANTIBACTERIAL,DRUGS,WITH APPROXIMATE MARKET SHARE,2008(%).35FIGURE 2(CONTINUED).36TABLE 13 MAJOR MANUFACTURERS OF ANTIBACTERIALS ANDTHEIR PRODUCTS,2009.36MAJOR INFECTIOUS BACTERIAL DISEASES.37BACTERIAL DIARRHEAL DISEASES.37Cholera.37,Frequency.37Treatment
24、.38Clostridium Difficile.38,Treatments under Development.38Campylobacter.39,Copyright BCC Research,Wellesley,MA USA,Web:,vi,PHM061A Infectious Disease Treatments:Global Markets,TABLE OF CONTENTS,Treatment.39EMERGING FOOD-BORNE/WATER-BORNE ILLNESSES.39,TABLE 14 CURRENTLY AVAILABLE TREATMENTS FOR,SALM
25、ONELLA AND THEIR MANUFACTURERS.40,HAEMOPHILUS INFLUENZAE B(HIB).41Vaccination.41TABLE 15 PROJECTED MARKET FOR HIB VACCINE,THROUGH,2014($MILLIONS).42,PNEUMONIA.42Current Treatment.42Vaccines.42TABLE 16 PROJECTED REVENUES FROM VACCINES ANDMEDICATIONS TO TREAT PNEUMONIA,THROUGH 2014($,MILLIONS).43,SEXU
26、ALLY TRANSMITTED DISEASES.43Chlamydia.43TABLE 17 PRIMARY ANTIBIOTICS TO TREAT CHLAMYDIA.44,Emerging Treatment.44Gonorrhea.44TABLE 18 PRIMARY ANTIBIOTICS TO TREAT GONORRHEA.45,Emerging Treatment.45Syphilis.45Chancroid.46STAPHYLOCOCCAL INFECTIONS.46,Emerging Treatments.47,Dalbavancin.47Telavancin.47Or
27、itavancin.47Ceftobiprole.48Ceftaroline.48TUBERCULOSIS.48TABLE 19 NUMBER OF CASES OF TB ANNUALLY,BY COUNTRY,2007.49,Frequency.49,United States.49European Region.50Drug-resistant Strains.50Current Treatments.50TABLE 20 PROJECTED GLOBAL REVENUES FOR TB DRUGS,THROUGH 2014($MILLIONS).51,Copyright BCC Res
28、earch,Wellesley,MA USA,Web:,vii,PHM061A Infectious Disease Treatments:Global Markets,TABLE OF CONTENTS,TABLE 21 CURRENTLY AVAILABLE TREATMENTS FOR TB ANDTHEIR MANUFACTURERS.51,Emerging Treatments.51URINARY TRACT INFECTIONS.52TABLE 22 CURRENTLY AVAILABLE TREATMENTS FOR UTIS ANDTHEIR MANUFACTURERS.53,
29、EMERGING TREATMENTS.53,Bacterial Interference.53Bacteriophage Therapy.53,Bacteriophage Therapy(Continued).54Bacterial Vaccines.55,Cationic Peptides.55Cyclic D,L-a-Peptides.56CHAPTER SIX:FUNGAL INFECTIOUS DISEASES.57OPPORTUNISTIC FUNGAL INFECTIONS.57PRIMARY FUNGAL INFECTIONS.57FUNGAL INFECTIOUS DISEA
30、SES.58TABLE 23 PROJECTED COST OF ANTIFUNGAL AGENTS TO TREATFUNGAL INFECTIONS,THROUGH 2014($BILLIONS).58,FIGURE 3 MARKET SHARE OF COMPANIES INVOLVED IN THE,TREATMENT OF FUNGAL INFECTIONS,2009(%).59,CANDIDIASIS.59Causes of Candidiasis.60Frequency.60Treatment.61TABLE 24 CURRENT MEDICATIONS FOR CANDIDIA
31、SIS,2009.61TABLE 24(CONTINUED).62,Future Market.62ASPERGILLOSIS.62TABLE 25 CURRENT MEDICATIONS FOR ASPERGILLOSIS,2009.63,COCCIDIOIDOMYCOSIS.63,Frequency.63Treatment.64,TABLE 26 CURRENT MEDICATIONS FOR COCCIDIODOMYCOSIS,2009.64,CRYPTOCOCCOSIS.64,Frequency.65Treatment.65TABLE 27 CURRENT MEDICATIONS FO
32、R CRYPTOCOCCOSIS,2009.65,MUCORMYCOSIS.65,Copyright BCC Research,Wellesley,MA USA,Web:,viii,PHM061A Infectious Disease Treatments:Global Markets,TABLE OF CONTENTS,Frequency.66Treatment.66TABLE 28 CURRENT MEDICATIONS FOR MUCORMYCOSIS,2009.66,PARACOCCIDIOIDOMYCOSIS.67,Frequency.67Treatment.67,TABLE 29
33、CURRENT MEDICATIONS FOR,PARACOCCIDIOIDOMYCOSIS,2009.67,PNEUMOCYSTIS CARINII.68Frequency.68Treatment.68,TABLE 30 CURRENT MEDICATIONS FOR PNEUMOCYSTIS CARNII,2009.69SPOROTYRICHOSIS.69,Treatment.69TABLE 31 CURRENT MEDICATIONS FOR SPOROTYRICHOSIS,2009.69,TRICHOSPORON INFECTIONS.70,Frequency.70Treatment.
34、70TABLE 32 CURRENT MEDICATIONS FOR TRICHOSPORON,INFECTIONS,2009.70ZYGOMYCOSIS.71,Frequency.71Treatment.71TABLE 33 CURRENT MEDICATIONS FOR ZYGOMYCOSIS,2009.71CHAPTER SEVEN:VIRAL INFECTIOUS DISEASE.72MAJOR DISEASES.72RESEARCH FUNDING.72TABLE 34 GLOBAL PROJECTIONS FOR VIRAL INFECTIOUS,DISEASE TREATMENT
35、S,THROUGH 2014($MILLIONS).73HIV/AIDS.73,TABLE 35 PROJECTED GLOBAL MARKET FOR HIV DRUGS,THROUGH 2014($MILLIONS).74SHIFTING PRIORITIES.74TABLE 36 10 LEADING GLOBAL HIV MANUFACTURERS,2010.74FIGURE 4 MARKET SHARE FOR TOP MANUFACTURERS OF HIVTREATMENTS,2009(%).75,EMERGING TREATMENTS.76,Gilead Sciences.76
36、Merck.76,Copyright BCC Research,Wellesley,MA USA,Web:,ix,PHM061A Infectious Disease Treatments:Global Markets,TABLE OF CONTENTS,ViiV Healthcare.76Tibotec.76,TMC 278.77COMMON PEDIATRIC VIRAL INFECTIONS.77POLIOMYELITIS.77DIPHTHERIA,TETANUS,PERTUSSIS(DTP).78TABLE 37 PROJECTIONS FOR DTP,POLIO,HIB COMBIN
37、ATION,VACCINE SALES,THROUGH 2014($MILLIONS).79,MEASLES,MUMPS,RUBELLA.79Measles.79Mumps.80Rubella.80,TABLE 38 PROJECTED GLOBAL REVENUES FROM MMR VACCINE,THROUGH 2014($MILLIONS).81CROUP.81OTITIS MEDIA(EAR INFECTIONS).81,Causes of Otitis Media.82Treatment.82TABLE 39 PROJECTED COSTS OF OTITIS MEDIA TREA
38、TMENTS,THROUGH 2014($MILLIONS).82,Pharmacological Intervention.82Surgical Intervention.83TABLE 40 GLOBAL SURGICAL COSTS FOR MYRINGOTOMY IN,PEDIATRIC PATIENTS,THROUGH 2014($MILLIONS).83,TABLE 41 GLOBAL SURGICAL COSTS FOR,TONSILLECTOMY/ADENOIDECTOMY IN PEDIATRIC PATIENTS,THROUGH 2014($MILLIONS).84INFL
39、UENZA.84INFLUENZA TREATMENTS.85TABLE 42 PROJECTED GLOBAL MARKET FOR INFLUENZA,TREATMENTS,THROUGH 2014($MILLIONS).85,FIGURE 5 ESTIMATED MARKET SHARE OF COMPANIES IN,INFLUENZA TREATMENT MARKET,2009(%).86,EMERGING TREATMENTS.86HEPATITIS.87TABLE 43 HEPATITIS CHARACTERISTICS,BY TYPE.87TABLE 43(CONTINUED)
40、.88TABLE 44 VACCINES AND MEDICATIONS FOR THE TREATMENTOF HEPATITIS,2010.88TABLE 44(CONTINUED).89,Copyright BCC Research,Wellesley,MA USA,Web:,x,PHM061A Infectious Disease Treatments:Global Markets,TABLE OF CONTENTS,TABLE 45 PROJECTED MARKET FOR HEPATITIS MEDICATIONSAND VACCINES,THROUGH 2014($MILLION
41、S).90,HEPATITIS A.90,TABLE 46 PROJECTED REVENUE FROM HEPATITIS AVACCINATION AND TREATMENTS,THROUGH 2014($,MILLIONS).91,HEPATITIS B.91,TABLE 47 PROJECTED REVENUE FROM HEPATITIS BVACCINATION AND TREATMENTS,THROUGH 2014($,MILLIONS).92,Emerging Treatments.92HEPATITIS C.92,TABLE 48 PROJECTED REVENUE FROM
42、 HEPATITIS C,TREATMENTS,THROUGH 2014($MILLIONS).93FIGURE 6 MARKET SHARES FOR HEPATITIS C TREATMENTS,2010(%).93FIGURE 6(CONTINUED).94,Emerging Treatments.94HERPES VIRUSES.94TABLE 49 HERPES VIRUSES THAT INFECT HUMANS.94TABLE 50 PROJECTED MARKET FOR HERPES SIMPLEX VIRUS,MEDICATIONS,THROUGH 2014($MILLIO
43、NS).95,HERPES SIMPLEX VIRUS TYPE 1(HSV-1).95HERPES SIMPLEX VIRUS TYPE 2(HSV-2).95Prevalence.96Emerging Treatment.96,Chiron.96GlaxoSmithKline.97Xenova/GlaxoSmithKline.97Avant Immunotherapeutics.97EPSTEIN-BARR VIRUS.98HUMAN HERPES VIRUS 6.98HUMAN HERPES VIRUS 8.98EMERGING HERPES TREATMENTS.98NanoViric
44、ides,Inc.98Cytogenix.99Alnylam Pharmaceuticals,Inc.99VARICELLA VIRUSES.99CHICKENPOX.99SHINGLES.100,Copyright BCC Research,Wellesley,MA USA,Web:,xi,PHM061A Infectious Disease Treatments:Global Markets,TABLE OF CONTENTS,TABLE 51 PROJECTED MARKET FOR VARICELLA VACCINES,THROUGH 2014($MILLIONS).101ENTERO
45、VIRUSES.101COXSACKIE VIRUSES.101CREUTZFELDT-JAKOB DISEASE(CJD).102EMERGING TREATMENTS.102,Quinacrine.102Pentosan Polysulphate(PPS).103OPPORTUNISTIC VIRAL INFECTIONS.103CYTOMEGALOVIRUS.103,Current Treatments.104TABLE 52 CURRENT TREATMENT OPTIONS FOR CMV,2009.104,KAPOSIS SARCOMA(KS).104HEMORRHAGIC FEV
46、ERS.105ARENAVIRUSES.106BUNYAVIRUSES.106FILOVIRUSES.106FLAVIVIRUSES.107,Frequency.107Current Treatment.108HUMAN PAPILLOMAVIRUS(HPV).108TREATMENT.108,TABLE 53 PROJECTED MARKET FOR HPV TREATMENTS,THROUGH 2014($MILLIONS).109,EMERGING TREATMENTS.109UPPER RESPIRATORY VIRUSES.109COMMON COLD.109SINUSITOSIS.
47、110RESPIRATORY SYNCYTIAL VIRUS(RSV).110TABLE 54 CURRENT TREATMENTS FOR RSV.111TABLE 55 PROJECTED MARKET FOR RSV TREATMENTS,THROUGH 2014($MILLIONS).111,Emerging Treatments.112,Arrow Therapeutics.112Alnylam Pharmaceuticals.112AstraZeneca/MedImmune.112ROTAVIRUS.113GLOBAL IMPACT.114TREATMENTS.114ROTATEQ
48、.114ROTARIX.114,Copyright BCC Research,Wellesley,MA USA,Web:,xii,PHM061A Infectious Disease Treatments:Global Markets,TABLE OF CONTENTS,TABLE 56 GLOBAL REVENUES FOR PEDIATRIC ROTAVIRUS,VACCINES,THROUGH 2014($MILLIONS).115,TABLE 57 GLOBAL ROTAVIRUS VACCINE SALES,BY,MANUFACTURER,2008($MILLIONS/%).115C
49、HAPTER EIGHT:PARASITIC INFECTIOUS DISEASE.116CAUSES OF PARASITIC DISEASE.116MALARIA.116,TABLE 58 PROJECTED GLOBAL REVENUES FOR MALARIALPREVENTION AND TREATMENT MEASURES,THROUGH 2014($,MILLIONS).117,CAUSES OF MALARIA.118MALARIAL TREATMENTS.118TABLE 59 AVAILABLE DRUGS FOR THE TREATMENT OF MALARIA,2009
50、.118,Current Treatments.119TABLE 60 PROJECTED GLOBAL REVENUE FROM MALARIAL,TREATMENTS,THROUGH 2014($MILLIONS).119,Evolving Treatments.119,GlaxoSmithKline.120Novartis.120Pfizer.120Sanofi-aventis.120Sigma-Tau.120MOSQUITO NETTING.120TABLE 61 MOSQUITO NETTING DISTRIBUTED,2006-2008.121TABLE 62 PROJECTED
