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1、LABORATORY SAFETY MANUALTABLE OF CONTENTSPageSection AEMERGENCY RESPONSE INFORMATION4Section BSAFETY PERSONNEL DIRECTORY5Section CCHEMICAL HYGIENE PLAN1.INTRODUCTION61.1 Purpose1.2 Policy1.3 Scope2.RESPONSIBILTY72.1 Chief Executive Office (CEO)2.2 Associate Chief of Staff/R&D2.3 Administrative Offic
2、er/R&D2.4 Chemical Hygiene Officer2.5 VA Subcommittee on Research Safety (SRS)2.6 Principal Investigators2.7 Employees3.GENERAL SAFETY REQUIREMENTS104.CHEMICAL PROCUREMENT AND STORAGE114.1 Procurement4.2 Storage4.2.1 General Guidelines4.2.2 Flammables4.2.3 Perchloric Acid4.2.4 Picric Acid4.2.5 Chlor
3、oform5. CHEMICAL LABELING146.SIGNS AND LABELS156.1 Signs Types6.2 Flammable Refrigerators7. HAZARDOUS CHEMICAL WASTE DISPOSAL157.1 Sewer Disposal 7.2 Contracted Disposal7.3 Waste Collection Procedures7.4 Toxic Use Reduction/Hazardous Waste Reduction8. PROCEDURES FOR USE OF HAZARDOUS LABORATORY CHEMI
4、CALS8.1 Compressed Gases8.2 Flammable Gases8.3 Toxic Gases8.4 Laboratory Procedures Involving Radioactivity8.5 Acids and Bases8.6 Solvents8.7 Formaldehyde8.8 Toluene8.9 Carcinogens8.10 Reactives and Explosives8.11 Reproductive Hazards8.12 Allergens and Sensitizers8.13 Chemotherapy Agents8.14 Biologi
5、cal Agents9. SPILLS AND ACCIDENTS239.1 Chemical Spills9.2 Mercury Spills9.3 Biological Spills9.4 Radioisotope Spills9.5 Spill Evaluation10.PROTECTIVE APPAREL AND EQUIPMENT2510.1 General Guidelines10.2 Types of Personal Protective Equipment10.2.1 Eyewear 10.2.2 Gloves10.2.3 Other Protective Equipment
6、10.2.4 Respirators11.ENVIRONMENTAL MONITORING2611.1 Monitoring Criteria11.2 Employee Record Access12.RECORDKEEPING 2712.1 Accident Reporting12.2 Medical Recordkeeping12.3 Chemical Inventory 12.4 Training Records13. EMPLOYEE INFORMATION AND TRAINING2814. EMERGENCY SHOWER AND EYEWASH EQUIPMENT2815.HOU
7、SEKEEPING, MAINTENANCE AND INSPECTIONS2915.1 Housekeeping15.2 Maintenance15.3 Passageways16.ACCIDENTAL EXPOSURES/MEDICAL SURVEILLANCE PROGRAM3016.2 Routine Surveillance16.3 Emergency First Aid Procedures16.3.1 Eye16.3.2 Cuts, Punctures, Needlesticks16.3.3 Chemical Burns16.4Injury Management Program1
8、7.SAFETY PROCEDURES3217.1 Fire Safety17.2 Electrical Safety17.3 Centrifuges17.4 Cryogenic Liquids17.5 High Vacuum Apparatus17.6 Heated Appliances17.7 Autoclaves17.8 Non-Ionizing RadiationAPPENDICESA. Table of Incompatible ChemicalsB. Laboratory Close-out ProceduresSECTION A. Emergency Response Infor
9、mationPhoneFire Emergency (Code Red)*20 or pull boxChemical Emergency *20 Radiation Safety Officer55853, *41-2745Industrial Hygienist54765, 55417Medical Center Safety Officer56330After Hours-Energy Center56300Police (for disruptive/dangerous behavior-Code 5)*21Cardiac Arrest/Unconsciousness (Code 99
10、)*22To report an emergency:Dial numberGive your nameGive your specific locationState the problemSECTION B. Safety Personnel DirectoryResearch & Development ServicePhoneAssociate Chief of Staff, R&DMichael P. Davey, Ph.D. M.D. 56789Deputy ACOS for R&DArchie Bouwer, Ph.D. 55125Chair, Subcommittee on R
11、esearch SafetyMarielle Gold , Ph.D.Chemical Hygiene OfficerWendy D. Trapp, B.S.55417Medical CenterSafety OfficerBill Stewart, CHSP56330Fire Safety/Chemical Pick-upDavid Quimby57752Industrial HygienistsJenika Schindlbeck, B.S. 54765Wendy Trapp, B.S., 55417Radiation Safety OfficerGlenda Villamar55853S
12、ubcommittee on Research Safety (current)Marielle Gold, Ph.D., ChairCharles Meshul, Ph.D., Neurocytology ResearchArchie Bouwer, A.O., ex officioResearch ServiceGlenda Villamar, M.S.Radiation Safety OfficerJanowsky, Aaron J. Ph.D.Research ServiceWendy Trapp, B.S.Chemical Hygiene OfficerKingery, Julie,
13、 MDPathology & Laboratory ServiceKy Dehlinger, D.V.M., ex officioVeterinary Medical OfficerRobert Johnson, B.S.Senior Research AssociateBenjamin SmithOHSU BiosafetyBrain LitostanskyEmployee Union Safety RepresentativeJenika Schindlbeck, B.S.Industrial HygienistJason Taylor, MD, PhDStaff Physician/ I
14、nfection Disease ResearchSECTION C. Chemical Hygiene Plan1. Introduction1.1. Purpose To educate laboratory personnel at Portland VA Medical Center (PVAMC) in the use of safe laboratory practices and procedures and of the hazards associated with chemicals and other hazardous materials; thereby reduci
15、ng the risk of exposure and preventing unnecessary injury or illness.1.2. PolicyPVAMC maintains a program capable of educating employees on a continuous basis and protecting them from unsafe practices and health hazards associated with hazardous chemicals in the laboratory. The program is designed t
16、o keep employee exposures below permissible limits and to ensure compliance with pertinent Federal, State, and local regulations. The program is also designed to protect patients, personnel, visitors, property, and the environment.1.3. ScopePVAMC continually strives to provide a learning, teaching,
17、public service, and research environment that is reasonably free from recognized hazards. Pursuant to Occupational Safety and Health Administration (OSHA) Regulations 29 CFR 1910.1450, the medical center establishes this Chemical Hygiene Plan (CHP) to protect employees, patients, visitors, property,
18、 and the environment from potential health hazards associated with the handling, use, and storage of hazardous chemicals in laboratories.This Chemical Hygiene Plan applies to all laboratory scale usage of chemical products at PVAMC. “Laboratory scale” is defined by OSHA as “work with substances in w
19、hich the containers used for reactions, transfers, and other handling of substances are designed to be easily and safely manipulated by one person. Laboratory scale excludes those workplaces whose function is to produce commercial quantities of materials.”The manual is not intended as an encyclopedi
20、a of chemicals and their hazards. It will not contain listings of the thousands of chemicals that employees may potentially encounter while working in research, teaching, and development. Although numerous chemicals and compounds may be referred to herein, for the most part, they will serve as illus
21、trations for broad categories of hazards, except in the case of chemical incompatibility charts or listings.The safe use of biological materials (e.g., potentially infectious medical waste such as human blood or other bodily fluids) requires control measures similar to those found in chemical safety
22、. However, biological agents may have the added dimension of infectious hazards, and require different disposal methods. For specific information on these agents, please consult the research Biosafety Manual as well the VA Medical Center Infection Control Manual, Section I: Blood borne Pathogens Exp
23、osure Control Plan (BPP) for proper work practices involving biological materials or BMBL http:/www.cdc.gov/biosafety/publications/bmbl5/. 2. Responsibilities2.1. Chief Executive Officer (CEO)2.1.1 Responsible for chemical hygiene within the institution.2.1.2 Provides support for and ensures that th
24、e appropriate laboratory facility is provided.2.1.3 Approves the selection of the Chemical Hygiene Officer (CHO) and VA Subcommittee of Research Safety (SRS) members2.2. Associate Chief of Staff/Research & Development2.2.1 Responsible for ensuring adherence with all phases of laboratory safety and e
25、lements covered in the chemical hygiene plan.2.2.2 Recommends to the CEO for approval the selection of the Chemical Hygiene Officer (CHO) and VA Subcommittee of Research Safety (SRS) members.2.2.3 Responsible to ensure compliance with regulatory requirements and safety laboratory work practices as o
26、utlined in the Chemical Hygiene Plan.2.3. Administrative Officer/Research & Development2.3.1 Supervise safe practice in the laboratory and ensure compliance.2.3.2 Develops and implements appropriate chemical hygiene policies and practices in conjunction with CHO and SRS.2.3.3 Provides administrative
27、 assistance in support of the activities of the VA Subcommittee of Research Safety (SRS) and the Chemical Hygiene Officer.2.3.4 Maintains a current and detailed inventory report for all hazardous chemical utilized by the Research Service.2.3.5 Works with the CHO and/or the Radiation Safety Officer (
28、RSO) to conduct investigations into incidents, in which employees have become seriously injured or ill, or where unsafe procedures and practices may have resulted in excessive employee exposures. This process may include official boards of inquiries and may involve lab closures.2.3.6 Ensure that req
29、uired training is updated and taken annually by all employees. Also ensure that established procedures and protocols are being followed with respect to the use, storage, spill control and disposal of hazardous chemical utilized in Research Service.2.4. Chemical Hygiene Officer (CHO)2.4.1 Monitor pro
30、curement, use, and disposal of chemicals used in the lab.2.4.2 Know the current legal requirements concerning regulated substances and seek ways to improve the chemical hygiene program. 2.4.3 Work with AO to develop appropriate chemical hygiene policies and practices.2.4.4 Works with the AO and/or t
31、he Radiation Safety Officer (RSO) to conduct investigations into incidents, in which employees have become seriously injured or ill, or where unsafe procedures and practices may have resulted in excessive employee exposures. This process may include official boards of inquiries and may involve lab c
32、losures.2.4.5 Develop and update Safety Checklist as necessary to ensure the safe handling and disposal of hazardous chemicals.2.4.6 Provides assistance in support of the activities of the VA Subcommittee of Research Safety (SRS) as a voting member.2.5. VA Subcommittee on Research Safety (SRS)2.5.1
33、Review protocols and grant proposals for research projects where biohazards, radioactive substances or hazardous chemical will be used. Reviews must be conducted and approved prior to initiation of protocols. The Subcommittee reserves the right to provide additional review of specific procedures (ev
34、en if the overall protocol has previous been reviewed and approved) prior to their initiation if they feel the proposal warrants additional review.2.5.2 Provide support to the AO/R&D and CHO as needed.2.5.3 Coordinate semi-annual Laboratory Safety Audits and review responses to deficiencies using th
35、e Lab Audit Checklist in Appendix C as a guideline. 2.5.4 Investigate incidents of unsafe conditions or employee injuries or illnesses involving hazardous substances and assure that prompt corrective action is taken to prevent recurrence.2.6. Principal Investigators2.6.1Ensure that employees comply
36、with the Chemical Hygiene Plan and other safety related policies.2.6.2Train employees under your supervision with regard to chemical handling and disposal of hazardous chemicals. If needed, the Chemical Hygiene Officer, members of the VA Subcommittee of Research Safety, and resources of the Medical
37、Center Safety and Risk Management Committee (SRMC) can be utilized.2.6.3 Ensure that employees under your supervision complete all mandatory safety training required by the Medical Center and Research Service.2.6.4Ensure that proper personal protective equipment (PPE) is available, used, and stored
38、properly in the laboratory.2.6.5 Ensure that less hazardous chemicals are substituted, where possible. Ensure that only the minimal quantities necessary are ordered to minimize potential exposure and waste. 2.6.6 Ensure that a current and detailed inventory for all hazardous chemicals is maintained
39、in each laboratory and that a copy is provided to the AO for R&D. A Safety Data Sheet (SDS) must be available and readily accessible for every hazardous chemical used in the laboratory.2.6.7Ensure that discrepancies found during laboratory inspections are corrected within 30 days of receiving the re
40、port and that a response is sent to the appropriate personnel. 2.6.8 Ensure that proper closeout procedures are followed according to the “R&D Service Policy and Procedures for Lab Closeout” in Appendix B. All chemicals no longer needed must be identified to assure proper disposition (waste disposal
41、 or reuse). All excess equipment must be decontaminated before it changes hands for resale or disposal. 2.6.9Ensure that employees observe the “No eating or drinking” rule in all laboratories. They are only to eat in offices separated from the labs by a door or in the break-room. 2.6.10Inform AO of
42、changes in protocols and procedures that involve variations in the fire and associated hazards of materials used in individual spaces. 2.6.11Ensure all employees are enrolled in PVAMCs Employee Health program. .2.7Employees2.7.1Read and comply with this Chemical Hygiene Plan and other safety related
43、 policies.2.7.2Promptly report unsafe conditions or unsafe use of hazardous chemicals to the respective supervisor.2.7.3Remain aware of the hazards of materials used in the laboratory and use them in a safe manner.2.7.4.Ensure that all primary and secondary containers of chemicals are properly label
44、ed with the identity of the chemical, its hazards and manufacturer information. Under certain circumstances (i.e. chemical containers are too small to accommodate a legible label), alternate forms of labeling is acceptable.2.7.5 Coordinate hazardous waste pick-ups by calling extension 57752 as neede
45、d. 2.7.6 Complete all required lab safety trainings3. General Safety Requirements3.1 Smoking, eating, drinking, mouth pipetting, and application of cosmetics or contact lenses are prohibited in the laboratory. These activities (excluding mouth pipetting) are only permitted in the designated areas, s
46、uch as separate offices and break rooms.3.2 Shorts, mini-skirts, and open-toe shoes shall not be worn while working in the laboratory. In addition, lab coats/gowns must be worn when working with corrosive or bio-hazardous substances.3.3 Contact lenses should not be worn in the laboratory when working with corrosive chemicals unless splash resistant goggles are worn. Contact lenses, especially soft contact lenses, will absorb certain chemicals an
