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1、P-1,CONTENT,S,A.NAD biosynthetic pathways and metabolism,B.NAD consuming enzymes in health and disease,C.Age-related diseases and cancer,D.Mechanisms of NAD Precursors in humans and,animal models,E.NAD and the hallmarks of aging,P-2,A.,N,AD biosynthetic,pathways and,metabolism,P-3,NAD biosynthetic p
2、athways and metabolism,Eric Verdin.(2015).Special Section 350,（,6265,）,:,P-4,NAD,biosynthetic pathways and metabolism in different cellular,compartments,.,B.,N,AD consuming,enzymes in health and,disease,P-5,NAD consuming enzymes in health and disease,E F.Fang,.(2017).NAD,+,:a key metabolic regulator
3、 with great,therapeutic potential:1120-1143.,P-6,NAD,availability,can,influence,the,activity,of,three,groups,of,master regulator enzymes,the,sirtuins,the,PARPs,and,cyclic,ADP-ribose,synthases.,Each group of enzymes regulate,many,biological,processes,and,can,thus,couple,changes,in,NAD,levels,with,a,w
4、ide,range,of physiological responses.,C.,A,ge-related diseases and,cancer,P-7,1980s,1930s,P-8,Age-related diseases and cancer could be the consequence of a decline in,NAD+concentrations,Amanda Garrido(2017).Trend in cancer 181,Age-related diseases and cancer,M,e,t,a,b,o,l,i,c,s,y,n,d,r,o,m,e,i,n,c,l
5、,u,d,i,n,g,cardiovascular,disorders,type,2,diabetes,and,obesity,Neurodegenerative,diseases,such,as,Alzheimer,and,Parkinsondiseases,arthritis,and osteoporosis,and,cancer,are,some of the diseases that,commonly,affect,human,health,during,aging.,D.,B,enefits and,mechanisms of NAD,precursors in humans,an
6、d animal models,P-9,Benefits and mechanisms of NAD,precursors in humans and animal,models,GSultani.(2017).Trends in Molecular Medicine23,P-10,Benefits and mechanisms of NAD precursors in,humans and animal models,GSultani.(2017).Trends in Molecular Medicine23,P-11,Benefits and mechanisms of NAD precu
7、rsors in,humans and animal models,GSultani.(2017).Trends in Molecular Medicine23,P-12,E.,N,AD and the hallmarks,of aging,P-13,NAD and the hallmarks of aging,GSultani.(2017).Trends in Molecular Medicine23,P-14,NAD and the hallmarks of aging,GSultani.(2017).Trends in Molecular Medicine23,P-15,NAD and the hallmarks of aging,GSultani.(2017).Trends in Molecular Medicine23,P-15,NAD and the hallmarks of aging,GSultani.(2017).Trends in Molecular Medicine23,P-15,P-18,
