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1、,場州大荸学SLE/APS患者妊娠的管理张育扬州大学医学院苏北人民医院风湿免疫科,場州大荸学育龄女SLE流行病学特点:性为主患病率:20-70/10万性别:男/女:1:9年龄20-39岁Yamamete Y,et al.Int J womens Health.2019:8:265-72,場州大荸学SLE的预后明显改善:1年存活率9597%5年存活率872%10年存活率80.9%10年存活率65.2%,冫場州大荸Decrease in Pregnancy loss rates in Patients withystemic Lupus Erythematosus Over a 40-Year P
2、eriodCHRISTINE A CLARK.KAREN A SPITZER and CARL A LASKIN6666715708-3对生育提出更高的要求!Clark Cetal.J Rheumata1mn,邕州太TABLE 1:Hormonal aud immume response differences between marital pregnancies.Immune and hormonal Response Normal pregnancylupus ad pignaThIEstradiol and progeteroneHisher in second and thind L
3、ower in seond and thireImpaired placental function andAltered immune regulationhiah in the third trimesterLow in lhe three lrirrrsehigh in the last trimsoud iout pregl aucy and Coutinuous B cell stimul t ionTreg cellsow lurber aud impairedLupus activtyChemokinesLOitCXCLIO/P-10Ficolin-3IncreaseIHigher concentrationProlactinHigher concentratlonLupus activityFco|n3:纤维胶凝蛋白3;Prolactin:催乳素de Jesus GR,et al.Autoimmune Dis,2019:2019:943490.dol:10.1155/2019/943490,
