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1、Table 1. Clinical characteristics of the subjects at baselineSamplesJSYAHYIHControlSample No.20191412Age4864610517456Sex (F/M)9/1110/97/76/6BMI(kg/m2)22.72.9623.81.6825.712.8422.642.51ALT (U/L)168.85142.15146.29123.78131.37109.1274.8965.02AST (U/L)133.2381.56127.16102.37156.68114.9795.3173.31Total b
2、ilirubin (mg/dL)4.052.644.522.413.973.161.261.19Direct bilirubin(mg/dL)2.531.833.562.662.731.921.41 1.33Indirect bilirubin(mg/dL)1.471.131.441.091.350.510.76 0.35Table 2. Identification of urinary biomarkers in JS cases. RtM+H+M-H-FormulaNameP-value1.85184.1916C9H13NO3Epinephrine0.030.41228.2365C9H1
3、3N3O4Deoxycytidine0.011.15262.3297C11H19NO6Methylglutarylcarnitine0.023.42247.1059C12H22O53-Hydroxydodecanedioic acid0.055.58149.2452C9H8O2Cinnamic acid0.001.18223.1942C10H9NO54-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid0.001.96181.2324C9H12N2O2Tyrosinamide0.002.11227.2702C10H14N2O4Porphobilin
4、ogen0.027.64289.4044C18H24O316b-Hydroxyestradiol0.010.96341.3072C21H40O35-oxo-heneicosanoic acid0.050.44197.0513C6H12O7Gluconic acid0.002.50265.1882C13H16N2O4Alpha-N-Phenylacetyl-L-glutamine0.012.81235.1163C12H14N2O35-Methoxytryptophan0.043.37105.0312C4H8O33-Hydroxybutyric acid0.035.52423.2180C12H23
5、O14PLactose 6-phosphate0.046.76591.3339C33H42N4O6D-Urobilinogen0.012.61261.1786C11H20N2O5L-gamma-glutamyl-L-leucine0.022.94281.1002C13H16N2O5L-beta-aspartyl-L-phenylalanine0.045.50254.1301C9H11N5O4Neopterin0.045.91247.1327C9H14N2O65,6-Dihydrouridine0.050.70194.2085C10H11NO32-Methylhippuric acid0.032
6、.23148.1141C5H9NO4L-Glutamic acid0.032.55424.4137C25H45NO4Linoelaidyl carnitine0.002.88217.1739C8H16N4O3N-a-Acetyl-L-arginine0.003.45213.0921C10H12O5Vanillactic acid0.004.98203.2635C8H18N4O2Dimethyl-L-arginine0.057.04293.3652C19H32O2Androstanediol0.051.19319.4167C11H15NO10Beta-Citryl-L-glutamic acid
7、0.021.74176.040C6H11NO3SN-Formyl-L-methionine0.002.23309.5566C12H17N5O5N2,N2-Dimethylguanosine0.013.85302.5163C15H17N3O4Indoleacetyl glutamine0.016.92480.3846C25H39NO6SN-Acetyl-leukotriene E40.008.85495.9742C27H44O8Pregnanediol-3-glucuronide0.011.16188.3128C10H7NO3Kynurenic acid0.042.28189.2368C6H6O
8、7Oxalosuccinic acid0.034.01193.2905C6H10O7Iduronic acid0.045.51186.7564C9H16O4Azelaic acid0.017.93213.4360C12H22O33-Oxododecanoic acid0.022.22381.4092C14H17N5O8Succinyladenosine0.006.48541.9970C27H42O11Cortolone-3-glucuronide0.021.24263.0144C9H12O7S3-Methoxy-4-Hydroxyphenylglycol sulfate0.011.7283.0
9、659C16H12O5Glycitein0.006.22382.4537C19H28O6S3b,16a-Dihydroxyandrostenone sulfate0.030.43396.0564C12H19N3O8S25-Taurinomethyl-2-thiouridine0.00Table 3. Identification of urinary biomarkers in YAH cases. RtM+H+M-H-FormulaNameP-value1.18223.1942C10H9NO54-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
10、0.001.96181.2324C9H12N2O2Tyrosinamide0.007.64289.4044C18H24O316b-Hydroxyestradiol0.011.26216.0146C10H9N5OKinetin0.012.11227.2702C10H14N2O4Porphobilinogen0.022.61188.0689C11H9NO2Indoleacrylic acid0.012.61130.0635C5H7NO3Pyrroline hydroxycarboxylic acid0.005.94463.4874C25H34O86-Dehydrotestosterone gluc
11、uronide0.032.25136.1113C5H5N5Adenine0.042.94235.1105C8H14N2O6L-beta-aspartyl-L-threonine0.025.83286.2001C15H27NO42-Octenoylcarnitine0.027.44467.3206C27H46O4SCholesterol sulfate0.000.47241.1267C10H16N4O3Homocarnosine0.010.96341.3072C21H40O35-oxo-heneicosanoic acid0.032.64409.4793C29H60nonacosane0.023
12、.67209.0771C11H12O4Benzylsuccinic Acid0.035.89247.1319C10H18N2O5L-gamma-glutamyl-L-valine0.010.48216.0224C4H10NO7PO-Phospho-4-hydroxy-L-threonine0.001.28443.1118C17H22N4O8SS-(4-Nitrobenzyl)glutathione0.002.55248.1070C10H17NO6Malonylcarnitine0.002.61235.1106C12H14N2O35-Methoxytryptophan0.013.35105.03
13、22C2H4N2O3Urea-1-carboxylate0.044.32200.0369C4H10NO6PO-Phosphothreonine0.025.5254.1390C13H19NO43-Indolecarboxylic acid0.011.24263.0144C9H12O7S3-Methoxy-4-Hydroxyphenylglycol sulfate0.041.7283.0659C16H12O5Glycitein0.048.04266.6464C9H16O93-Deoxy-D-glycero-D-galacto-2-nonulosonic acid0.001.73177.0224C5
14、H10N2O3SCysteinylglycine0.004.84204.0662C11H11NO35-Methoxyindoleacetate0.016.22382.4537C19H28O6S3b,16a-Dihydroxyandrostenone sulfate0.012.23309.5566C12H17N5O5N2,N2-Dimethylguanosine0.007.91461.8676C26H38O7Retinyl beta-glucuronide0.021.58180.05C6H7N5O28-Hydroxy-7-methylguanine0.002.63172.9896C6H6O4SP
15、henyl sulfate0.002.88188.0338C10H7NO3N-Acetylisatin0.016.57540.2884C24H47NO10Spsychosine sulfate0.037.26460.2827C30H39NO3Arachidonoyl-AMC0.022.7163.0407C9H8O3Enolphenylpyruvic acid0.033.92343.1388C16H24O8Iridotrial glucoside0.015.67389.0929C16H22O11Monotropein0.00Table 4. Identification of urinary b
16、iomarkers in YIH cases. RtM+H+M-H-FormulaNameP-value0.74173.0915C8H12O42-Octenedioic acid0.023.40130.0479C5H7NO3Pyroglutamic acid0.003.40265.1126C13H16N2O4Alpha-N-Phenylacetyl-L-glutamine0.011.08166.0705C6H7N5O3-Methylguanine0.022.23180.0861C7H9N5O7-Aminomethyl-7-carbaguanine0.010.57203.1489C10H18O4
17、Sebacic acid0.032.13315.0737C13H14O9Beta-D-Glucopyranuronic acid0.043.81215.117C14H14O2(+)-(1R,2R)-1,2-Diphenylethane-1,2-diol0.000.40212.0313C10H13NO43-Methoxytyrosine0.052.86201.9941C3H7NO5S2Cysteine-S-sulfate0.043.40248.0926C10H17NO6Malonylcarnitine0.014.34560.1141C15H23N5O14P2Adenosine diphospha
18、te ribose0.004.80368.0904C14H25NO102-Acetamido-2-deoxy-6-O-a-L-fucopyranosyl-D-glucose0.000.48216.0132C9H10ClNO33-Chlorotyrosine0.001.89400.1078C15H23N6O5SS-Adenosylmethionine0.022.15357.1026C20H36O5Prostaglandin F1a0.012.86292.0322C11H17NO6SHawkinsin0.044.79544.1176C27H29NO11Adriamycin0.025.51318.1
19、475C19H27NO3nateglinide0.000.5286.0707C4H7NO2-Pyrrolidinone0.010.75143.1158C8H14O22-Octenoic acid0.011.97502.0894C18H35N3O13D-Glucosaminide0.002.86354.0206C13H11N3O5S22-Hydroxytenoxicam0.003.40287.0994C19H26O2Androstenedione0.005.64389.0938C18H18N2O8Dopaxanthin0.006.66541.2570C27H42O11Cortolone-3-gl
20、ucuronide0.012.79180.3030C6H7N5O28-Hydroxy-7-methylguanine0.026.79479.2260C25H36O911-Oxo-androsterone glucuronide0.001.19319.4167C11H15NO10Beta-Citryl-L-glutamic acid0.013.85302.5163C15H17N3O4Indoleacetyl glutamine0.000.98269.0042C18H22O2Estrone0.001.55218.9994C11H12N2O35-Hydroxy-L-tryptophan0.013.2
21、275.0208C10H16N2O5SBiotin sulfone0.015.28385.1671C27H46OCholesterol0.015.59383.1494C27H44O7-Dehydrocholesterol0.006.79200.1337C10H19NO3Valproylglycine0.007.99267.336C8H16N2O4S2L-Homocystine0.020.44251.0491C10H12N4O4Deoxyinosine0.011.12320.0779C11H15NO10Beta-Citryl-L-glutamic acid0.002.11279.0697C13H
22、16N2O5L-beta-aspartyl-L-phenylalanine0.012.64227.0940C9H12N2O5Deoxyuridine0.013.11195.0685C10H12O4Homoveratric acid0.023.96243.1072C13H24O41,11-Undecanedicarboxylic acid0.015.28283.1111C13H16O7p-Cresol glucuronide0.000.57255.3176C16H32O2Palmitic acid0.022.44230.9989C10H20N2O4Spermic acid 0.004.20193.0905C6H10O7D-Glucuronic acid0.015.44209.0544C10H10O5Vanilpyruvic acid0.005.86199.1267C12H24O2Dodecanoic acid0.01
