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1、第三章 固有结缔组织 Connective Tissue proper,重点：,疏松结缔组织的七种细胞三种纤维和基质的结构,结缔组织的结构,结缔组织Connective tissue,细胞 Cell,细胞间质Extracellular matrix,纤维 Fiber,基质 Ground substance,组织液 Tissue fluid,结缔组织的分类 Classification,固有结缔组织 Connective tissue proper血液和淋巴 Blood and lymph Fluid connective tissue骨和软骨 Bone and Cartilage Suppor
2、ting connective tissue,结缔组织的来源,胚胎时期的间充质 间充质细胞（mesenchyme)无定形基质All of CTs originate from mesenchyme embryonic CT,The meshwork of embryonic connective tissue in the mesoderm that gives rise to the connective tissue of the body,blood vessels,and lymph vessels.,结缔组织的功能（Function）,支持，连接，充填，营养，保护，修复和防御的功能,
3、In a word,CT have functions of connecting,supporting,protecting,nutrition,defense and repairing,固有结缔组织 Connective tissue proper,疏松结缔组织 Loose connective tissue致密结缔组织 Dense connective tissue脂肪组织 Adipose tissue网状组织 Reticular tissue,疏松结缔组织 Loose connective tissue,Loosely arranged fibers and abundant cel
4、ls,成纤维细胞 Fibroblast,巨噬细胞 Macrophage,浆细胞 Plasma cell,肥大细胞 Mast cell 脂肪细胞 Fat cell,未分化间充质细胞 undifferentiated mesenchymal cell,白细胞 Leukocytes.,疏松结缔组织的细胞Cells in loose connective tissue,成纤维细胞 fibroblast,EM:粗面内质网 高尔基复合体 游离核糖体-function:synthesize fibers and ground substance,Synthesis of collagenous fiber
5、in three steps:a.synthesis of procollagen(RER)process(Golgi)procollagen out of cellb.procollagen tropocollagen fibrilc.fibril collagenous fiber,*fibrocyte:still state or inactive fibroblast-structure:spindle-shaped,smallN:small,dark stained Acidophilic cytoplasmaEM:less organelles-function:become in
6、to fibroblast for repairing,巨噬细胞 macrophage,EM:溶酶体 吞噬体 吞饮小泡 残余体,功能:1.趋化性和变形运动 2.吞噬作用 特异性吞噬作用 非特异性吞噬作用 3.参与和调节免疫反应 4.分泌作用,浆细胞 plasma cell,EM:rich in parallelly arranged RER,free ribosome and Golgi complex-function:synthesize and secrete immunoglobulin,Ig-antibody,肥大细胞 mast cell,EMMembrane bound granu
7、lesA few MitochondriaA little RER,嗜碱性颗粒-异染性颗粒 肝素（heparin）组胺（histamine）嗜酸性粒细胞趋化因子（eosinophil chemotactic factors of anaphylaxis,ECF-A）类胰蛋白酶(tryptase)，胃促胰酶(chymase)，糜蛋白酶(chymotrypsin)白三烯（leukotriene）功能：引起过敏反应,脂肪细胞fat cells(adipose cells),未分化间充质细胞undifferentiated mesenchymal cell,白细胞 leukocytes:中性粒细胞 n
8、eutrophil,嗜酸性粒细胞 eosinophil，嗜碱性粒细胞 basophil 淋巴细胞 lmphocyte 单核细胞 monocyte,summary,A.Classification of CT B.7 types of cell in LCT1.fibroblast,collagenous fiber synthesis 2.macrophage,Macrophage&the mononuclear phagocyte system3.plasma4.mast cell5.fat cell6.undifferentiated mesenchymal cells7.leukocyt
9、e,Questions:,1.Describe the process of collagen fibers formation2.What kind of cells present in loose connective tissue?And what are the functions of those cells?3.What is(are)the structure cell(s)of connective?,纤维 fibers胶原纤维 Collagenous fiber弹性纤维 Elastic fiber网状纤维 Reticular fiber,胶原纤维Collagenousfib
10、er(white fiber)LM:直径1-20 um HE 染色呈粉色，带状,EM:胶原原纤维 fibrils20-200nm in diameter 64nm 横纹胶原蛋白 collagen(type I and III)胶原原纤维collagenous fibril 胶原纤维 collagenous fiber,*formation:Extracellular polymerizecollagen(type I and III)collagenous fibril collagenous fiber,弹性纤维elastic fiber(yellow fiber)LM:直径 0.2-1.0
11、 um 特殊染色呈蓝紫色或棕褐色 EM:弹性蛋白 elastin 微原纤维 microfibril 10-12 nm,网状状维 reticular fiber LM:直径0.2-1.0 um 嗜银纤维 Argyrophilic fiber EM:III 型胶原 type III collagen 64nm 横纹 分布：网状组织，,基质 ground substance 蛋白多糖 proteoglycan 糖蛋白 glycoprotein 组织液 tissue fluid,蛋白多糖 proteoglycan-糖胺多糖 glycosaminoglycans:硫酸软骨素 chondroitin su
12、lfate硫酸角质素 keratin sulfate硫酸皮肤素 dermatan sulfate硫酸肝素 heparin sulfate透明质酸 hyaluronic acid:2.5um蛋白 protein*分子筛 molecular sieve,糖蛋白 glycoprotein:纤维粘连蛋白 fibronectin 细胞cellsfibronectin胶原纤维collagen 蛋白多糖 proteoglycan-层粘连蛋白 laminin-软骨粘连蛋白 chondronectin,组织液 tissue fluid,组织 tissue 动脉 artery 组织液 Tissue fluid 静
13、脉vein，毛细淋巴管 血液 blood steam 脱水 dehydration水肿 oedema,致密结缔组织Dense connective tissue-纤维多，细胞少-连接 connection-支持supporting规则致密结缔组织 Dense regular CT;不规则致密结缔组织Dense irregular CT弹性组织 Elastic CT,规则致密结缔组织 regular DCT:,不规则致密结缔组织 irregular DCT:,脂肪组织 adipose tissue-白色脂肪 white fat T:单泡脂肪细胞-棕色脂肪细胞 brown fat T:多泡脂肪细胞,网状组织 reticular tissue 网状细胞Reticular cells,网状纤维reticular fibers 基质ground substance-分布:造血组织 hemopoietic tissue 淋巴组织 lymphatic tissue,Summary,Loose connective Tissue3 fibers and 7 kinds of cells,
