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1、加巴喷丁与普瑞巴林区隔,辉瑞医学部,Pfizer Confidential Internal Use Only Draft Not for Distribution,Do Not Detail,2,加巴喷丁和普瑞巴林的化学结构差异,合成的支链氨基酸抑制性神经递质g-氨基丁酸(GABA)的结构衍生物,Pfizer Confidential Internal Use Only Draft Not for Distribution,Do Not Detail,Bockbrader HN,et al.Clin Pharmacokinet.2010;49:661669.,3,钙离子通道调节剂的药物作用机
2、制,加巴喷丁与普瑞巴林作用于钙离子通道a2d亚单位1抑制钙离子内流，并随之抑制兴奋性神经递质的释放1普瑞巴林对Ca2+通道a2d亚基的亲和力比加巴喷丁高(40 nmol/L vs 32 nmol/L)2,，,Pfizer Confidential Internal Use Only Draft Not for Distribution,Do Not Detail,Taylor CP.Pain.2009;142:1316.Chiechio S.Clin Drug Investig.2009;29:203-213.,4,加巴喷丁与普瑞巴林的药代动力学差异,Pfizer Confidential I
3、nternal Use Only Draft Not for Distribution,Do Not Detail,Bockbrader HN,et al.Clin Pharmacokinet.2010;49:661669.,5,普瑞巴林vs加巴喷丁最小稳态血药浓度,Pfizer Confidential Internal Use Only Draft Not for Distribution,Do Not Detail,Bockbrader HN,et al.Clin Pharmacokinet.2010;49:661669.,6,加巴喷丁与普瑞巴林的疗效差异,小样本(n=32)替换治疗研究
4、表明，普瑞巴林对PHN的止痛作用是加巴喷丁的6倍。,Pfizer Confidential Internal Use Only Draft Not for Distribution,Do Not Detail,Ifuku M,et al.Pain Med.2011;12:11121116.,7,加巴喷丁与普瑞巴林的疗效差异,对比加巴喷丁，普瑞巴林的疼痛减分更多，且服用剂量较低。,Pfizer Confidential Internal Use Only Draft Not for Distribution,Do Not Detail,Bockbrader HN,et al.Clin Pharmacokinet.2010;49:661669.,8,谢 谢,
