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1、第五章 Multi-Component Reactions,Multicomponents reactions(MCRs)are those reactions in which three or more reactants come together in a single reaction vessel to form a new product which contains portions of all the components,ConvergencyComplexityProductivity,SelectivityAtom economyDiversity,一、多组分反应的历
2、史,Ivar Karl Ugi(1930-2005),the inventor of the most significant isocyanide based MCRs.,二、多组分反应涉及的反应机理,1.离子机理,异腈参与的多组分反应大多为离子机理。,Angew.Chem.Int.Ed.1998,37,2234,2.自由基机理,Angew.Chem.Int.Ed.2003,42,3490,3.周环反应机理,Tetrahedron Lett.1998,29,5855,4.混合机理自由基和负离子组合,Angew.Chem.Int.Ed.1998,37,152,三、金属催化的多组分反应,四、多组
3、分反应展望,Hardly a field in organic chemistry has evolved faster over only a couple of years than MCRs.However,the very large MCR space of 1020 is only explored marginally.Future research in the area of MCRs will include the discovery and design of novel MCRs,combinations of MCRs and traditional reactio
4、ns,experimental improvements in solid-and liquid-phase,enantio-and diastereo-selective variations,and more and more applications in drug discovery,material science,bioconjugates,and agrochemical compounds.,第六章 串联反应新进展,Tandem reactions,in which multiple reactions are combined into one synthetic operation,have been reported extensively in the synthetic chemistry literature.,Angew.Chem.Int.Ed.2009,48,7064 7068,重排反应自由基反应Michael加成反应过渡金属催化的反应Fischer卡宾配合物的反应周环反应其他反应,
