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1、,Idiopathic Adult Nephrotic Syndrome:,A Clinicopathological Study and Response to Steroid in a Sub-Saharan African Country,Li Shuang,Dai Qing,Zheng Wei,Repoerters:,Content,Introduction of NS,Patients and Methods,Results,Discussion,Conclusion,Idiopathic nephrotic syndrome(NS),is determined by a prote
2、inuria higher than 3g/24h associated with hypoalbuminemia,with no kidney inflammatory lesions or immune complex deposits.,Definition,Clinical translation,podocyte injury,25%-30%glomerulonephritis in adult,50%of glomerulonephritis,chronic kidney disease,Aims of the study,A,Epidemiology,B,Clinico-biol
3、ogy.,C,Histology,D,Therapeutics&Progression profile,Patients,teen years of age and above,Nephrology Department at Aristide Le Dantec University Hospital during 2001.01 to 2010.10,Methods,Descriptive study of different variablesBiveriat analysis,Electronic questionnaire elaborated by Epi,Analysis,Dat
4、a collection,Population distribution,Results(156 out of 202 patients were primitive(77%),Symptoms,Laboratory details,Renal biopsy,Treatments,Prognosis,Age the mean age was 17.7-41.7 years the group of 15-25 years was the most representative with 46 of patientsGender men represented 72(112 patients)w
5、omen represented 28(44 patients),Population distribution,Symptoms,40%,63%,hypertension,hypertension was found in 63 patients.,edema,edema was the most frequent type of presentation found in 98 patients.,Laboratory details,Renal biopsy,treatment,lifestyle measures,drug treatment,sufficent caloric die
6、t(100%)fluid restriction(13.4%)sodium restriction(95%)a low potassium diet(5.7%),diuretics(91.5%)antiprotein uric agents(43%)ACE-inhibitors(100%)anticoagulation(8.4%)steroid(95.9%),alone(85.8%),Steroidtherapy,with cyclophosphamide(7.6%),with azathioprine(2.5%),Prognosis,complete remission,patial rem
7、ission,relapse,23.7%,4.45%,5.1%,Discussion,1,4,2,3,Prevalence,Age,Histology,progress,77%,41.2%,12%,Akpechis study,Demestudy,Prevalence of idiopathic NS,our study,mean age of 29 years,02,Age,our study,age group of 25-34years,Demes study,Histology,FSGS(局灶性节段性肾小球硬化),T,.,MN(微小病变型),MCD(膜性肾病),45.6%,5%,43.
8、4%,our study,Demestudy,75%,6%,12%,The cause of difference,renal biopsy,PROGRESS,33%,28%,Chronic kidney disease,The progress towards chronic kidney disease was noted in 33%.,Remission,In our study the progression was favorable with remission in 57 patient.,Conclusion,A,NS is frequent in our country,B,.,C,Remission is very low,D,Commom lesionFSGS,Early diagnosis is important,
