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1、我在泰♥晤♥土&hearts服♥上读到篇文章IreadthispieceinTheTimes是一个需要换气管的小女孩aboutthislittlegirlwhoneedsanewwindpipe.她叫汉娜沃伦NamesHannahWarren.她家人在跟欧洲一位医生合作HerfamilysworkingwiththisdoctorinEurope.保罗马基亚里尼博士Dr.PaoloMacchiarini.我的研究方向是通过开♥发♥生物合成气管Thefocusofmyresearchistrachealtransplants在
2、干细胞的参与下withthehelpofstemcells进行气管移植bydevelopingbiosynthetictracheas.你等于是让身体相信Soyourebasicallytrickingthebody植入物已经是自身的一部分了intothinkingtheimplant,salreadyapartofyou.你有兴趣做我助手吗Willyoubeinterestedinassisting?有当然有Yes.Yes.不知道你是否有兴趣合作Iwaswonderingifyouwouldbeinterested用我们的气管在老鼠身上做实验incollaboratingonrattrial
3、stotestourtracheas.当然-欢迎加入Absolutely.-Welcometotheteam.这是美国首例人工气管Sothisisthefirstartificial-tracheatransplant移植手术intheU.S.我想把文章的焦点放在汉娜身上andIwantHannah,sjourneytobethefocusofthepiece.手术进行得很顺利Surgerywentwell.我已经观察你一段时间了Ihavewatchedyouforawhilenow.你做的一切堪称奇迹Whatyoudid,itwasamiracle.保罗我不应该Paolo,Ishouldnt
4、.似乎没什么科学基础Thesciencedoesntseemsound.这与你擅长的科学不同lt,snotexactlyyourkindofscience.我承认我不理解IwilladmitIdontgetit.手术刀Knife.她在做过气管移植后活得Aftertheoperation,sheshealthyandhappy很开心很健康withherdonortrachea.芝加哥汉娜沃伦五号♥病人术后两个月汉娜沃伦将会成为生物合成气管移植HannahWarrenwillbetheyoungestpatient史上最年轻的病例evertoreceiveabiosynthetict
5、rachealtransplant.好了这里停一下Okay,stoprightthere.把这里换成马基亚里尼医生1.etsswapthisouttoplayoverDr.Macchiarinitalking第一次诊断后的谈话abouttheinitialdiagnosis.我觉得还需要加一点父母的镜头IthinkwestillneedalittlemoreB-roll但节目马上就要定版了withtheparents,butweareclosetolocking.你没事吧-对我没事Youokay?-Yeah,mokay.嗨Hi.我正在聊你呢Iwasjusttalkingaboutyou.嗯贝妮
6、塔Uh,Benita.达里尔Daryl?我打电♥话♥是Icalledto,um-我打电♥话♥是想告诉你Icalledtotellyoushe,uh-她走了shesgone.什么What?汉娜已经不在了Hannahsgone.什么叫她不在了What-whatdoyoumeanshesgone?出现了并发症Itwas-Therewerecomplications.她的肺部因I为经历了太多次治疗Her-herlungs,afterallthetimeinthehospital,她她的身体无法再shejust-herbodycouldnt,um.
7、汉娜去世了Hannahsgone.我们一直跟她待在一起她的情况不断恶化Wewerewithher,andshejustkeptgettingworse.我们以为她能挺过来Wethoughtmaybeshewasgonna-可是thatitwouldpass,but,uh-妈你电♥话♥响了Mom,yourphone.工作上的事吗不是工作Isitwork?-No,it,snotwork.你为什么想梳辫子了孩子Whatsupwiththebraids,kiddo?你一周从没梳过两次相同的发型Ihaventseenyourepeatahairstyletwice,更别说一周
8、三次了letalonethreetimes,inaweek.爸爸喜欢我这么梳Dadlikedmyhairthisway.我也很想他Imisshim,too.但你看起来真的很棒ButIthinkyoulookgreat.准备好去上学了吗Youreadyforschool?你来这里做什么Whatareyoudoinghere?我想确保你没事Iwantedtomakesurethatyoureokay.你不接我电♥话♥不回我短♥信♥Yourenotansweringmyphonecalls,mytexts.你不该来这里Youshouldntbe
9、here.我知道你听说了汉娜的事IknowyouheardaboutHannah.我只是想确保你没事贝尼塔Ijustwantedtomakesurethatyoureokay,Benita.我只是想确保你没事贝尼塔Ijustwantedtomakesurethatyoureokay,Benita.你不是告诉我她有好转吗Ithoughtshewasgettingbetter.出现了并发症并发症一Therewerecomplications.-Complications.脆弱的原生组织“Fragilenativetissue.让她的肺部越来越虚弱Weakeningofthelungs我看过报告了保
10、罗我懂医学I-1readthereports,Paolo.Iknowthemedicine.可你却告诉我她会好转Butyoutoldmeshewasgettingbetter.她病得很重Shewasverysick.她本来就要死了Andshewasgoingtodie.我尽力了Itried.你以为我不难过吗Youthinkthatmnotupset?但我不会放弃的ButIwontgiveup.我没有放弃的权利Idonthavetherighttogiveup.保罗别这样我做不到No,Paolo,don,tI-1cantdothis.咱们就直接承认了吧好吗1.etsjustcallitwhati
11、tis,okay?承认什么Whatisit?这是个错误Amistake.各位同事董事会成员Colleagues,boardmembers,很高兴大家能出席wearesogladtohaveyouhere这个重要的时刻forthismomentousoccasion.明天我们将进行首例生物人造支架Tomorrowwewillperformthefirst-everhumantransplant的移植手术usingabioartificialscaffold.我们的病人叫安德马力亚姆贝耶恩OurpatientisAndemariamBeyene,一位生活在冰岛的36岁a36-year-oldEri
12、treanPhDstudent厄立特里亚博士生livinginIceland.两年前他的气管长出了Twoyearsago,hedevelopedamalignanttumor恶性肿瘤inhiswindpipe.多次放疗和手术干预Theyhavetriedradiationandsurgicalintervention.都失败了Allfailed.所以他的医生把他介绍给了我们Sohisdoctorsreferredhimtous.大家都知道我们只有在Asyouallknow,weonlyhaveapproval病人病情危急标准治疗无效时toperformthisprocedureascompas
13、sionateuse,才会批准这种手术alastresort.我们为贝耶恩先生量身定做了Wehavedesignedabiosynthetictrachea一套生物合成气管tailor-madetoMr.Beyenesanatomy,精确到每一微米downtothelastmicrometer.这例手术将使我们学院成为Andthistrulyisthebreakthrough这种医疗手段的全球目的地thatwilllaunchusasaglobaldestination这无疑是一种重大突破forthiskindofmedicine.女士们先生们1.adiesandgentlemen,请允许我展
14、示再生医学的未来Ipresenttoyouthefutureofregenerativemedicine.几周内它就会长出人体组织Withinweeks,itwillgrowtissue,才成为一个真正的活气管transformingintoanactual,livingtrachea.安德马力亚姆贝耶嗯2号♥病人第一例生物气管移植马基亚里尼医生很抱歉Dr.Macchiarini,Iamsorry.我不想再做手术了Inolongerwishtohavethesurgery.我们觉得风险实在太大Wefeelitistoorisky.有顾虑是很正常的贝耶恩先生Itiscomplete
15、lynaturaltohaveconcerns,Mr.Beyene.那根气管是塑料的Thetrachea,itsplastic.你怎么能保证它在我体内会起作用Howcanyoubesureitwillworkinsidemybody?你这里误会了Thereyoumisunderstand.它不是塑料的Itisnotplastic.气管是医用级的Thetracheaismedical-grade高分子纳米复合材料制成polymericnano-compositematerial.我可以进来吗当然IfImay.-Yeah,ofcourse.贝耶恩先生你在冰岛研究熔岩洞Mr.Beyene,youre
16、studyinglavatubesinIceland.对吗-对Isthatright?-Yes.我认为细胞再生过程Ibelievetherecellularizationprocess也是这个道理isjustlikethat.当火山爆发时Whenavolcanoerupts,地下的熔岩河形成了管洞undergroundlavariverscreatetubes.熔岩干涸后这些管洞留了下来Whenthelavadrains,thetubesremain,但它们变得坚如磐石butnowtheyrerocksolid.成为了地球的一部分TheybecomeapartoftheEarth.也就意味着持
17、久永恒Andthatmeanstheylastforever.你的干细胞对Thatswhatyourstemcellswilldo合成气管也是这个作用tothesynthetictrachea让它永远成为你的一部分tomakeitlastforeverasapartofyou.你要让我丈夫做第一例受试者Youreaskingmyhusbandtobethefirst却不保证手术一定有效butoffernoguaranteetheprocedurewillwork.是我们保证不了No,Wecannotofferguarantees滥做保证是不负责任的becauseitwouldbeirrespo
18、nsibletodoso.医学上不存在绝对可靠一说Nothingisguaranteedinmedicine.就在一年前Evenjustayearago,你的选择还很有限youroptionswouldhavebeenmuchmorelimited.现在你很幸运能成为第一个Youareveryluckytobethefirst.你的医生让你来找我们Yourdoctorsreferredyoutous因为其他治疗方案统统失败becausetheothertreatmentsfailedyou.你的预期寿命只剩六个月了Youcouldhaveaslittleassixmonthstolive.你要
19、是想看着儿子长大这就是最好的机会Thisisyourbestchancetoseeyoursongrowup.好吧Okay.好吧Okay.不投入个人感情是很难的1thinkitsverydifficulttokeepanemotionaldistance,尤其这个病人还是个孩子especiallyifitisachild.你还撑得住吗Howyouholdingup?真希望自己能麻木一点IwishIfeltnumb.我现在心里Ijustfeel五味杂陈everything.你休息一下吧BGiveyourselfabreak,B.别那么着急走出来Yourenotonaschedulehere.一定
20、要难受过才会好Itsgonnatakewhatittakes.你知道吗汉娜沃伦和约翰Youknow,withHannahWarrenandJohn.死的人也太多了itsjustawholelotofdeath.丽兹怎么样了HowsLizzi?她蛮安静的Shesreallyquiet她应该是想在我面前装作无事Ithinkshespretendingtobeokayforme,这反而让我更内疚更难受了whichmakesmefeelguilty,whichmakesmefeelworse.她跟她爸的关系真的很好Shesjustsuchadaddysgirl.真的让我很心碎Andthatbreaks
21、myheart.至少你还有心可以碎Atleastyoustillhaveahearttobreak.是啊痛苦让我们向死而生Yeah,thepainremindsuswe,realive.这还不错Itsawesome.工作好吗-还好Workisgood?-Workisgood.工作还好Workisgood.那篇报道进展如何了Hey,howsthatpiececomingalong?没进展了呢Hey,itsnot.因为Its.这是一篇报道未来医学的特别节目aspecialaboutthefutureofmedicine.本应该给人希望It,ssupposedtobehopeful.可我现在没故事可
22、写了AndnowIdonthaveastoryatall.那他呢-他怎么了Whatabouthim?-Whatabouthim?把焦点转移到他身上Shiftthefocustohim,youknow?马基亚里尼医生创造奇迹的人Dr.Macchiarini,MiracleMan-代际医学的先驱alookatthepioneerOfgenerationalmedicine.再生医学-没错Regenerative.-Exactly.那汉娜怎么办ButthenwhataboutHannah?你仍可以把她安排进主叙事中Shedstillbepartofthemainstory.医学上的突破总是伴随着挫折
23、Medicalbreakthroughsarealwayspavedwithsetbacks.不代表马基亚里尼的研究ItdoesntmeanthatMacchiarini1Swork就不值得相信isntworthbelievingin.聚焦在点燃大家希望上Holdontothehopeful.这可是你的专长Ifanybodycanmakeithappen,itsyou.从什么时候开始疼的Whendidthepainstart?过去几周都断断续续的Um,offandonforthelastfewweeks.我以为是压力太大Ijustthoughtitwasstressorsomething.是刺
24、痛钝痛还是灼痛Wouldyoudescribethepainassharp,dull,orburning?刺痛就像啊Sharp,like-Aah!就像被人捅了一样“奥1.ikesomeonesstabbingme.0w.需要做全血细胞计数肝酶1.etsgetaCBC,liverenzymes,尿检腹部和骨盆的CTurinetest,andaCToftheabdomenandpelvis,外加30亳克的妥拉多止痛plus30milligramsofToradolforthepain.-所以是阑尾炎么不是阑尾炎Soitsmyappendix?-It,snotyourappendix.什么不不不Wh
25、at?No,no,no,no,no.我有一个女儿她才九岁Ihaveadaughter.She,snineyearsold.她刚失去了父亲Shejustlostherfather.我绝对不能倒下Icanthavesomethingwrongwithme.我们只想做些检查确认卜.情况Wejustneedtorunsometeststoseewhatsgoingon.医生他们在等你呢Doctor,theyrewaiting.你要给谁打电♥话♥吗Isthereanyoneyouwanttocall?你好打扰一下Hi,excuseme.一嗨嗨Hi.-Hi.谢谢你能过来我很抱歉
26、Thankyouforcoming.msorry.没事接到你电♥话♥我很开心No,no,mgladyoucalled.-现在还痛吗还痛Hasthepainsubsided?-No.而且我觉得更疼了Ithinkitsworse,actually.-医生怎么说啥都没说Whatdidthedoctorsay?-Nothing.就做了一堆测试也没人通知情况Theyjustranabunchoftests,andnoonestoldmeanything.把我一个人晾在这儿vejustbeensittingherebymyself.CT扫描显示你有子♥宫&hear
27、ts;肌瘤YouCTscanshowsuterinefibroids.什么那是什么癌症吗What?Whatisthat?Isthatcancer?完全不是这很常见Notatall.Theyreverycommon.介意我看一下吗好的IsitokayifItakealook?-Yeah.一行吧行Yeah?-Okay.-可能会有点疼没事Thismighthurtalittlebit.-Okay.Allright.好吧Okay.我能摸到到两个Yeah,Icanfeeltwo.应该跟葡萄柚差不多大TheyreaboutthesizeOfgrapefruits.什么What?没有听上去那么糟糕Itsou
28、ndsmuchworsethanwhatitis.别担心他们会帮你割掉的Dontworry.Theywillhavethemremoved.所以我必须得手术么SoIhavetohavesurgery?对但这手术很常见Yeah,butitsaverycommonprocedure.医生一定会把细节交代到的msureyourdoctorwillwalkyouthrougheverything.你会没事的Youregonnabefine.相信我Trustme.2012斯德哥尔摩他一上来就让你加班啊Hesgotyouworkinglatealready?我在做准备mpreparing.这是医生的工作I
29、t,ssomethingdoctorsdo.你也该试试的了解Youshouldtryit.-Noted.等文章发表了我睡觉的时间还多呢Illsleepwhenmpublished.你为什么不喜欢他Whydontyoulikehim?我谁都不喜欢1dontreallylikeanybody.这倒不假Thatstrue.可是呢咽喉手术在外科医生中并不受欢迎Still,sofewsurgeonswanttooperateonthethroatatall,而他却引入了干细胞再生andhethrowsinstem-cellregeneration.你对他的研究不感兴趣吗Arentyouintereste
30、dinhiswork?是呢是呢我觉得这一切Yes,yes,Ifinditallvery都非常有趣interesting.你个混♥蛋♥Youreanass.你来看看这个1.ookatthis.他必须识别气管周围的手术平面Hehastoidentifythesurgicalplanesborderingthetrachea,避免肿瘤扩散avoidtumordissemination,同时不暴露出喉头allwithoutexposingthelarynx,甲状腺食道thethyroid,theesophagus.你有发表意见的权利Saywhatyouwant.但马基亚里尼
31、医生确实很有种Dr.Macchiarini1Sgotsomeballs.这就是成功所需的吧有种Iguessthatswhatittakes,huh-somenicebigballs?抱歉我不是要有意冒犯你Sorry,Ididntmeantooffendyou.是呢你就是想说我没种Yes,Ihavetinyballs.一位优秀外科医生知道什么时候不该动刀Youknow,agoodsurgeonknowswhennottocut.得了吧我受够了总是畏畏缩缩Fuckthat.mtiredofbeingonthevergeofsomething.过谨慎而切不干净这项研究极具开创性Tooafraidto
32、makethecut-thisisgroundbreakingwork.我一定要参予mgettingin.你小小心点就行Justwatchyourback.我总是很小心Ialwaysdo.斯文森医生Dr.Svensson.马基亚里尼医生Dr.Macchiarini?Uh.试验似乎进行得很顺利Oh,thetrialsseemtobeproceedingnicely.是啊Uh,yes.一切正按计划进行Um,wereonschedule.很好Good.目前有什么好消息吗Anyexcitingconclusionssofar?目前你知道还没有Well,nothing-youknow,nothing还没
33、有切实的成果reallydeterminableyet.当然我现在还Ofcourse,Iwontbeabletotrulydiscern还什么都看不出来要等到anyresultsuntil-对等到你完成试验才行Yeah,untilyoucompletedthetrials,ofcourse.你应该能想象得到我对于试验结果Asyoucanimagine,mmveryanxious十分期待toseeanyresults-positiveorotherwise.就是那些植入了人造气管的Well,onthetestrats试验老鼠thathavereceivedsynthetictracheas,目前
34、为止还没有发现负面反应sofarnonehaverespondednegatively.那那太好了Well,that-thatisexcellent.但你也知道我们还在收集数据Butasyousaid,werestillgatheringdata.这个试验的目的thepurposeofthistrial就是为了观察客观结果istowitnessobjectiveresults,ofcourse.当然这是当然Ofcourse,ofcourse.请问是有什么因素引起了MayIask,isthereanythinginparticular你的关注吗-没完全不是thatisconcerningyou?
35、-Oh,no,notatall.我百分之百相信你的专业医生Ihavecompletefaithinyourresearch,Doctor,还有我的专业aswellasmyown.那就先不打扰了lljustleaveyoutoyourwork.好吧Okay.是的Yeah.谢谢-没问题Thankyou.-Yeah,noproblem.哦谢谢太谢谢rOh,thankyou,thankyou,thankyou.天呐快扶我起来Oh,myGod,please.真希望我对你也能有这种影响Wow,IwishIhadthateffectonyou.48小时断绝咖♥啡♥因&hearts
36、;48hourswithoutcaffeine?我名字今天被写啥了WhoamItoday?我帮他们拼好了你的名字Ispelledyournameforthem.感觉好点没-嗯嗯Yourefeelingbetter?-Mm-hmm.感觉像轻了两个曲萄柚Iam.Liketwograpefruitslighter.谢谢你真的Thankyou,really.我的荣幸Pleasure.保罗Paolo.过去几个月我们都失去了很多wevebothbeenthroughalotoflossthepastfewmonths.我知道自己不会死在里面可是AndIknowIwasntdyinginthere,butI
37、-我还是很害怕Iwasreallyscared,andit.就Itjust-这次事件为我打开了新视角itputthingsinperspectiveforme.我们在一起可能会害我丢了工作名誉扫地Ustogether,itcouldcostmemyjob,myreputation,但我认为为了我们的感情值得冒这个险butIthinkthisthingwehave,itsworththerisk.我也如此Forme,too.有人批评您Youveheardthecriticism-在拿这些病人冒险thatyou,rereallytakingachancewiththesepatients.对此你怎
38、么看Whatdoyousaytothat?我从小受到的教育告诉我Iwasraisedtobelievethatifyou.哪怕只有一线机会也要抓住ifhaveevenonechance,youneedtotakeit,因为要么我们放任病人死去becauseeitherthatpatientwilldie,要么我们可以做些新尝试orwetrytodosomething,evenifitsnew.作为一名医生或是作为一个人Asadoctorand-andasahumanbeing,I我扪心自问过我们有权说不吗Iaskmyselfareweallowedtosayno?我觉得没有1dontthink
39、weare.不久之后当你接到Andwhenyougotthatcalllater她去世的电♥话♥时that-thatshehadpassed.-Mm.这对你的打击一定是毁灭性的Ithadtobedevastatingforyou.我一直在想Icouldntstopthinking.那个决定真的正确吗didImaketherightdecision?我拼尽全力去救她了吗DidIdoeverythingtosaveher?世界上有这么多病人Therearesomanypatientsallaroundtheworld都需要这个手术whoneedthisprocedure
40、.我们应该为所有这些人Weshouldreallytrytoachievethis做到这一点forallofthem,因为即便要直面失败becauseeveninthefaceoffailure,我们都该心存希望Weshouldkeephopealive.大家今天干的不错Greatjobtoday,guys.马基亚里尼医生你能稍留几分钟Dr.Macchiarini,doyoumindstayingbehind看一下录制安排吗forafewminutestogoovertheschedule?晚安各位Goodnight.当然可以Ofcourse.所以So?所以So.我还有一些后续问题要问你Wel
41、l,Ihavesomefollow-upquestionsforyou这就是未来时间大概在thataregonnahappen.是吗-把门关上好吗Really?-Behindcloseddoors,yeah.很抱歉你要经历这些msosorryyouhadtogothroughthis.没关系的Itsokay.就是留道疤而已Itsjustgonnabeascar.总有一天我们会生活在一个Onedaywewillliveinaworld不需要开刀就能治病的世界wherewewonthavetocutpeopleopentofixthem.你会看到的Youllsee.你曾有过疑虑吗Doyouever
42、haveanydoubts?当然有过OfcourseIdo.真的吗Really?-Mm-hmm.因为你似乎总是信心满满Causeyouseemsosureofallofit.哪怕是那些担心的事Eventhethingsthatcouldgowrong,最后都成了真thathavegonewrong.你依然勇往直前youjustkeepmovingforward.我常常会想起那些前辈们Ithinkalotabouttheoneswhocamebeforeme.比如托马斯斯塔兹1.ikeThomasStarzl-他开创了第一例肝移植手术hestartedthefirstlivertransplan
43、ts.他的第一批病人都死了Hisfirstpatientsdied.-Hmm.或是克里斯蒂安巴纳德OrChristiaanBarnard.他做了第一例心脏移植手术heperformedthefirsthearttransplant.大家对他口诛笔伐Peoplethrewrocksathim.所有人都觉得他疯了Everybodythoughthewascrazy.我相信大家看他的眼神msurepeoplelookedathimthesameway就跟你现在看我一样thatyou,relookingatmerightnow.汉娜死后我确实失去过信心WhenHannahdied,Ididlosefa
44、ith.但是以上那些医生Butthesedoctors,they-他们也坚信过努力过坚持过theybelieved,theyworked,theypersevered直到拼出了一条路untiltheyfoundtheirway.作为第一个吃螃蟹的人Beingtheonetotrysomethingnew,你需要把个人得失放在一边nomatterthepersonalcost,关键是要推动医学进步isvitaltomovemedicineforward.这至关重要It,svital.我相信我们所做的事AndIbelievethattheworkthatweredoing会拯救很多生命isgoingtosavemanylives.我也这么相信Ibelieveitwill,too.嗨亲爱的我在巴塞罗那想念你Hi,mylove.mhere,missingyouinBarcelona.柠檬树已经在等着你了Thelemontreesarereadyforyou.我等不及要去吃寿司卷了Oh,thereisasushirollwithmynameonit贝妮塔-哦对一起午餐Benita?-Hmm?Oh,yeah,lunch.准备好了吗-抱歉,Youready?-Sorry.Yeah.很好Good.嗯-过来来嘛Mm.Comeon,c
