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1、真实故事改编生日女孩娇好你好Hithere.Hi.真高兴见到你Sogladtoseeyou.凯西,麻烦一下,好吗？Kathy,couldyoutakethat?谢谢Thankyou.帮必治妥药厂卖♥♥药是我的职责而且我告诉你ItsmyjobtomarketthisdrugforBristol-Myers,andmtellingyou,除非味道像口香糖否则小孩不肯吃kidswontgoforitunlessittasteslikebubblegum.克劳利先生,你要迟到了好,谢谢,拜Mr.Crowley,yourelate.Allright.Thankyou.Bye.
2、时尚遥控汽车1962年雪佛兰跑车”大家都直接走过去Everyonejustwalkedby.”海绵宝宝纳闷地大叫为什么大家都不买♥♥我们的报纸?Whywontanyonebuyournewspaper?1SpongeBobwonderedaloud.”派大星说他们一定不喜欢摇滚乐”Theymustberockhaters/saidPatrick.约翰!把她还给我!她现在是我的了！John!Giveitbacktome!Shesminenow!等我一下,好吗?还给我,约翰！Givemeaminute,okay?Giveitbacktome,John!记住我们脸到哪了,
3、好吗？Yousaveourspot.Gotit?你最好把我的费欧娜还我！YoubettergivemebackmyFiona!妈,救命！Help,Mom!救我!她要杀我!我要毙了你！Helpme!Shestryingtokillme!mgonnagetyou!你逃不了的!不!妈,救我！Youcan,tescape!No!Mom,helpme!把她还给我Justgiveitbacktome.妈!她要杀我!梅根凯瑟琳克劳利Mom!Shestryingtokillme!MeganKathrynCrowley.如果姊杀了娇哥哥就别想开派对rIfyoukillyourbrother,youcannoth
4、aveyourparty.为什么?他偷r费欧娜Whynot?HestoleFiona.我没偷她,我绑&hearts深♥她我要拿她来索取赎金1didntstealher,Ikidnappedher.mholdingherforransom.放了肉票Releasethevictim.准备开派对了Timetogetreadyforyourparty.我们必须赶快让产品上市Wevegottogetmovingontheproductlaunch.约翰,我在等法务部问覆mjustwaitingonlegal,John.该死！Damnit!我刚错过电车了我再打给你.Ijustmissedmy
5、train.mgonnahavetocallyou.好的,你何时需要？Iagree.Howsoondoyouneedit?愈快愈好我下礼拜要跟老板报告Assoonaspossible.mpresentingtomybossnextweek.约翰,上车了,快点！John,wereloadingupthevanrightnow.Comeon!准备上车了,凯特？我叫珍Okay,wereadytoroll,Kate?MynameisJane.妈,凯特是昨天的看护我很抱歉Katewasyesterday,Mom.Iamsosorry.中介公♥司&hearts汰常换看护给我们Thewayth
6、eagencyshufflesdaynursesonus,他们应该用编号♥取代名字的youdthinktheyd,youknow,giveyouanumberinsteadofaname.好了,约翰Okay,John.约翰,快点,上车了John,comeon,getyourbuttinthecar.约翰John.你要带滑板吗？对AreyoubringingyourRipStik?Yes.非带不可吗？对Doyouhaveto?Yes.真麻烦等等,我得拦出租车.apain,thatswhy.Wait,Igottacatchacab.嗨,出租车,嘿、嘿,拜托？Hi.Comehere.H
7、ey,hey.Hello?爸会在那里和我们会合吧？当然Daddysmeetingusthere,right?Absolutely.我相信他会准时到的Iamsurehehaseverythingundercontrol.出租车！Taxi!需要帮忙吗？Youneedahand?好极了,抱歉、抱歉,我赶时间Great.mSorry,Imsorry.mkindofinahurry.开始了Go.加油、加油、加油Comeon,comeon,comeon,comeon,comeon,comeon.太好了！Yes!好耶！他答应会准时到的Hetotallypromisedhedbeherebynow.他在路上了
8、,宝贝,他在路上了Hesonhisway,baby.Hesonhisway.嗨洛位Hi,guys.快过去亲她我知道Getinthereandgiveherakiss.Iknow.我不听、我不听快去、快去Idontwannahearit.Idontwannahearit.Go,go,go.生日快乐,我来了Happybirthday.Imadeit.耶!耶!Yay!Yay!许愿吧,梅根Makeawish,Megan.谁要吃蛋糕？Whowantscake?我要!我要！Ido!ldo!排成一排,否则没蛋糕1.ineupsinglefile,ornocakeforyou.好了,有几位小朋友？我先!我第一
9、！Allright,howmanydowehave?mfirst!Mefirst!不行,我比较大排到最后面去No,mthebigguy.Backtotheendoftheline.费欧娜要去哪里？So,whereisFionagoing,anyway?棒棒糖乐园吗？1.ollipop1.and?爸,我八岁了,不是小宝宝了meight,Daddy.mnotababyanymore.她要开车去南极看企鹅ShesdrivingtoAntarcticatoseethepenguins.真的吗?那很远耶Really?Thatsprettyfaraway.她为什么不去波特兰动物园？Whydoesntshe
10、justgotothePortlandZoo?那里也有很多企鹅Theyhavealotofpenguinsthere,too.你没听说过冒险吗？是哦Haventyoueverheardofadventure?Yeah.她这一去要好几年It,sgonnatakeheryears.她不带行李吗？Wontsheneedasuitcase?这是冒险肩险不需要带行李Itsanadventure.Youdontneedasuitcaseonanadventure.我不知道妫:怎么想如果我要去冒险Well,Idontknowaboutyou,butifIwasgoingonanadventure,我会带行李
11、Iwouldtakeasuitcase.那是因为你是商人没错,我是Thatscauseyoureabusinessman.Thatsright.Iam.而败八岁了,生日快乐,我爱（Andyoureeightyearsold.Andhappybirthday.AndIloveyou.我也爱你,爸1.oveyou,too,Daddy.晚安,明早见晚安Goodnight.Seeyouinthemorning.Goodnight.晚安Nighty-night.祝娇有个美梦Sweetdreams.晚安,爸GoodnighDad.晚安,爸晚安,小家伙Goodnight,Daddy.Night,buddy.
12、庞贝氏症研究消息庞贝氏症是一种肌肉萎缩症患者寿命最长九年庞贝氏症患者肌肉无力庞贝氏症治疗理论罗勃特史东希尔博士着史东希尔教授酵素研究先驱庞贝氏症主要医学研究员罗勃特史东希尔博士内布拉斯加州林肯内布拉斯加州大学(402)5550125没回电F班再试喂？喂,史东希尔博士吗？Hello?Hello,Dr.Stonehill?你在听吗?喂？是的Areyouthere?Hello?Yeah.我是约翰克劳利不知道你有没有收到我的留言ThisisJohnCrowley.Idontknowifyouvegottenanyofmymessages.谁?约翰Who?John.我的天Jesus.我很想和你谈谈我从很
13、多研究员那里得知minterestedinspeakingwithyou.Iunderstandfrommanyresearchers.方便的话,我想和你谈谈.havingaconversationwithyouifthatsconvenient.现在方便吗？Isthisagoodtimetotalk?史东希尔博士?喂？Dr.Stonehill?Hello?混♥蛋♥混♥蛋♥?”Asshole.Asshole?夜班护士刚刚走了Thenightnursejustleft.现在几点了Whattimeisit?我想你Imissedyou.真可怜,
14、我还是很紧张Thisispathetic.mstilldressed.我可以帮你放松Icouldhelpyouwiththat.凯特,你好Ohmy.Kate!Hi!Youreearly.你来早了已经6点了这位是我叫约翰克劳利6:00.Haveyoumet.mJohnCrowley.约翰是我丈夫Johnismyhusband.那就好Gladtohearit.对,今天要加强她的呼吸治疗Yeah,letsupherbreathingtreatmentstoday.怎么了？只是感冒,就严重塞住了Whatsgoingon?Justacold.Shesawfullycongested.以防万一,打给医生了
15、吗？我留过话了Callthedocjusttobeonthesafeside?Yeah,Ileftword.甜心?我要去上班了,好吗？Sweetie?mgonnagotowork,okay?要好好的哦Feelbetter.拜拜Bye-bye.我们已经成功地把药推销给医师了Werealreadydoinggreatmarketingthedrugtophysicians.若要直接推销给病人就得用更强的策略Itsourdirectmarketingtopatientsweneedtobeefup.克劳利先生,抱歉打扰了Mr.Crowley,mreallysorry.艾琳在在线,她有要事找你Aile
16、ensontheline,shereallyneedstospeaktoyou.好,谢谢,我接一下电♥话♥嘿Okay,thankyou.mjustgonna.Hey.我们在医院,医生要梅根住院观察We,reatthehospital.ThedocwantsMeganunderobservation.她还好吗？记得将手♥机♥带在身上Issheallright?Justkeepyourcellwithyou.好,我能做什么吗？一旦有消息,我会再打给你Okay.CanIdosomething?llcallyouwhenIknowmore.我得去
17、看梅根了一有消息,我就会打给你,好吗？IshouldreallygetbacktoMegan,sollcallyouassoonasIknowanything,okay?拜,爱（Bye.1.oveyou.请问一下先生？Excuseme,please.Sir?我女儿梅根克劳利刚进来住院观察Mydaughter,MeganCrowley,wasbroughtinforobservation.是的,其实他们正把她移到加护病房♥Yeah.Actually,theyremovinghertotheICU.在哪里？在那边Where?Thatway.艾琳约翰Aileen.John.她有没有告诉
18、你费欧娜将要开遥控车去旅行？HasshetoldyouaboutthetripthatFionastakingwithherremote-controlledcar?有,她说了甜心,娇说得对Yeah,yes,shedid.Youreright.That,sright,sweetie.娇想看所有的企鹅,不是吗？Youregonnaseeallthepenguins,arentyou?她会寄明信片给姊Shemightsendsomepostcardsorsomethinglikethat.沿路有很多有趣的东西没事的1.otsofgoodstufftoseealongtheway.Itsokay.比
19、如说冰山、北极熊.likeicebergsandmaybeapolarbear.海豹如何？Howaboutsomeseals?如你所知,庞贝氏症患者身体各部分肌肉会逐渐无力Asyouknow,Pompepatientssuffermuscledeteriorationineverypartofthebody,因此呼吸道并发症是这疾病不可避免的症状sothissortofrespiratorycomplication,well,thatsjustaninevitablefactofthedisease.克劳利先生、克劳利太太Mr.Crowley,Mrs.Crowley,梅根的治疗效果不佳Mega
20、nisnotrespondingwell.我们能做的都做了,但她Okay?Now,wevedoneeverythingwecan,butshesjust.很抱歉,我们无能为力Theresnothingmorewecando.msorry.如你所知,她已经超越一般庞贝氏症病童的平均寿命Asyouknow,shewasalreadywellpastthelifeexpectancy,for,youknow,Pompekids.毕竟,不光是肺的问题Afterall,itsnotjustherlungs,okay?她的心脏、肝脏等器官都受到影响Herheart,herliver,theseorgans
21、havebeencompromised造成致命性地扩大andwouldvebecomefatallyenlarged.我真希望庞贝氏症有药医可惜就是没有Now,IwishthatwehadadrugtotreatPompe,butwesimplydont.我真的很抱歉msoverysorry.听着,或许1.ook,maybe.或许知道梅根的痛苦快结束了你们会比较欣慰点MaybeyoucanfindsomesmallcomfortinknowingthatMeganssufferingwillbeover.或许这也是种福气Maybeyoucanseethisasablessing.梅根？救命！M
22、egan?Help!救命!救命!梅根？Help!Help!Megan?救命!救命！Help!Help!宝贝,妫听得到吗？Babygirl,canyouhearme?拜托,快来人帮帮忙!321室！Please,someonecomehelp!321!梅根克劳利,321室!紧急急救！MeganCrowley,room321,please!CodeBlue!宝贝,妈妈在这里快!呼叫海德医生Babygirl,Mamashere,allright?1.etsgo!PageDr.Heder.心跳停止!这边Asystole!Yeah,rightthroughhere.听得到吗?听得到妈妈吗？Canyouhe
23、armyvoice?CanyouhearMama?开始施压我来换气管Startingcompressions.llswitchherout.在这边,快点撑着点,梅根Overhere,please.Quickly.Hanginthere,Megan.撑着点,宝贝我得让她离开Hanginthere,baby,okay?1needtobagher.艾琳？请让一让Aileen?Someroomrightthere.让我们处理,好吗？1.etusin,allright?拜托,克劳利太太.住手！Please,Mrs.Crowley,let.Stopit!让我们救她！1.etushelpher!拜托梅根!艾
24、琳？Please.Megan!Aileen.肾上腺素,体重每公斤0.1毫克知道了Epinephrine,0.1milsperkig.Gotit.还是没心跳,没数据Stillnopulse.Noreading.别算体重了,快拿来!艾琳、艾琳Forgettheweight,comeon,getitinthere!Aileen,Aileen.0.1毫克好0.1epi.Itsallright.加油,梅根,加油增加点滴量Comeon,Megs.Comeon.Comeon.IVpush.每隔几秒给一次肾上腺素还是没反应Okay,justgivetheepiacoupleseconds.Stillnon-r
25、esponsive.准备电击电击Allright,chargethedefib.Charging.你女儿是个斗士Yourdaughterissomefighter.她会没事的我的天Shesgonnabeokay.Oh,myGod.听好,她还是很虚弱Now,look,shesstillaverysickgirl,obviously,但她的生命迹象进步了我很审慎乐观buthervitalsignshaveimprovedandmcautiouslyoptimistic.你意思是我们躲掉了那个福气,是吗？So,Iguessyoucouldsaywedodgedthatblessing,huh?克劳利
26、太太,这些是给梅根的谢谢、谢谢Mrs.Crowley,thesecameforMegan.Thankssomuch.Thankyou.嘿,约翰？Hey,John?等你准备好就开始Anytimeyoureready,man.你要跟大家说明产品上市计划？Yougonnatellusabouttheproductlaunch?约翰,你还好吗？John,youokay?我得走了Ihavetogo.约翰John.你要去哪？内布拉斯加州Whereyougoing?Nebraska.内布拉斯加州大学林肯市生化学院打扰一下,有位先生要见你Excuseme,please.Theresagentlemanhere
27、toseeyou.最好坐下来等吧Bestmakeyourselfcomfortable,hon.哦,天啊Oh,dear.先生、先生刚离开的就是史东希尔博士,抱歉Sir,sir.ThatsDr.Stonehill.Hejustleft,msorry.谢谢不客气Thankyou.Yeah.史东希尔博士！Dr.Stonehill!嘿,史东希尔博士！Hey,Dr.Stonehill!史东希尔博士？Dr.Stonehill?什么事？我是约翰克劳利Yeah?mJohnCrowley.好的你有没有收到我的留言？Okay.Didntyougetanyofmymessages?什么留言？Whatmessages
28、?最近一个月我留了三、四通留言给你1leftyouthreeorfourmessagesinthelastmonth,最后一通留言的前一晚你还挂了我电♥话♥andyouevenhunguponmethenightbeforelast.你在说什么?我从没挂你电♥话♥Whatthehellareyoutalkingabout?Ineverhunguponyou.史东希尔博士我有两个孩子得了庞贝氏症Dr.Stonehill,twoofmykidshavePompe.哦,我的天Oh,Jesus.我很遗憾Well,msorry.这种病很严重Ater
29、ribledisease,但你不该大老远跑来找我but,hell,youshouldnthavecomeallthiswaywithouttalkingtome.我做研究,不看病人Idoresearch,son.Idontseepatients.我有兴趣的就是你的研究Well,itsyourresearchthatminterestedin.我看过所有关于庞贝氏症的报导vereadallthejournalarticlesonPompedisease,而且所有医学研究员都说你的理论最有可能成功andalltheresearchersouttheresaythatyourworkholdsthe
30、mostpromise.说重点吧,你要我做什么？Gettothepoint,son.Whatdoyouwantfromme?我上周差点失去了我的女儿,Wealmostlostmydaughterlastweek.我必须听听你的研究Ineedtohearaboutyourresearch.你的孩子有基因缺陷Yourkidshaveageneticdisease.他们缺少一种酵素Theyremissinganenzyme无法转化肝糖whichmetabolizesacertainkindofsugar,glycogen.这是庞贝氏症患者的缺陷ItsdefectiveinPompepatients.
31、这种糖大量储积在肌肉细胞内So,thissugarbuildsupinthemusclecells,尤其是心肌、骨骼肌、横隔膜especiallyintheheart,theskeletalmuscles,thediaphragm,导致呼吸困难whichiswhytheyhaveahardtimebreathing.是的,那些我都知道大家都在生产醉素Yeah,Iknow.Iknowalotaboutthat.Everybodysmakinganenzyme,你可以整天帮孩了打酵素butyoucaninfusekidsalldaylongwiththeirenzyme,但那是没用的因为酵素不会进
32、入细胞中anditsnotgonnadoanygood,causeit,snotgonnagetintotheircells.懂吗？Understandwhatmsaying?懂,意思是如果把糖Yeah,sothatmeansthatifyouputthesugar.别打岔抱歉Dontinterrupt.Sorry.我在制♥造♥不同版本的薛素mmakingadifferentversionofthisenzyme.我的酵素有生物标记甘露糖6磷酸盐Myenzymehasabiologicalmarker,mannose6-phosphate.只有我能复♥
33、制♥基因里的磷酸转移mtheonlyonethatsclonedthegeneforphosphotransferase.只有我能复♥制♥基因里的催化mtheonlyonewhosclonedthegeneforuncoveringenzyme,所以我可以让更多甘露糖6磷酸盐进入溶体蛋白soIcangetmoremannose6-phosphateontothelysosomalprotein,并把大量的有效酵素andIcandeliveramoreeffectiveamountofenzyme送进细胞中intothecells.所以大家才会引用我的研
34、究Thatswhypeoplearecitingmywork.你也才会从文献中看到我的名字Thatswhyyoureadmynameintheliterature.我可以把更多酵素送进细胞中Icangetmoreenzymeintothecells.怎么了,莎尔？K殳听说过糖生物学吗？What,sthematter,Sal?Notuponyourglycobiology?我以为博士只是你的绰号♥IthoughtDocwasjustyournickname.不,这个人是个天才他将有重大医学突破No,thatmansagenius.Hesonthevergeofascientific
35、breakthrough.喋,还真看不出来Wow.Whoknew?我没有什么突破这只是个理论,不是疗法mnotonthevergeofanything,kid.Thisisatheory,notatherapy.我只是个学者mjustanacademic.知道我有多少研究经费吗？不知道Yougotanyideahowshittymyfundingis?No.内布拉斯加州大学付给足球教练的年薪UniversityofNebraskapaystheirfootballcoach比我整个医学研究预算还多没人在乎这种研究Nobodyspayingattentiontothiswork.我的一半补助金都
36、没被批准Halfmygrantsdon,tgetapproved.我没有经费将理论制♥造♥成实际药物Idonthavethemoneytomakemytheoryintoauseablemedicine.你的孩子几岁了？Howoldareyourkids?六岁和八岁Sixandeight.听好,帮你自己一个忙回家好好陪孩子1.ook,doyourselfafavor.Gohomeandspendtimewithyourkids.趁他们还在时,好好陪他们Enjoyemwhiletheyrestillhere.多少？什么东西多少？Howmuch?Howmuchwhat?
37、要多少钱才能证明你的理论Howmuchmoneywouldittaketoproveyourtheory,并制♥造♥成实际药物？tocreateyourversionofthemedicine?我需要五十万元资助实验室dneedhalfamillionbucksjusttofundthelabwork.所以你需要我我需要你?为什么？Thatswhyyouneedme.Ineedyou?Why?因为我是儿童庞贝氏症基金会的创办人BecausemthefounderofthePompeFoundationforChildren.我研究这个病十年了Ivebeenworki
38、ngonthisdiseasefor10years.从没听说过这个基金会Ihaveneverheardofyouguys.那是因为我们相当新,还在筹备阶段Thatsbecausewererelativelynew.We,rejustinthegearing-upphase.你何时需要钱?现在有最好Howsoondoyouneedagrant?Nowwouldbegood.钱还没全募完,不过很快就会有了Well,notallthemoneysinplace,butitwillbe,andsoon.真是令人兴奋的时刻Thisisaveryexcitingtime.谢了谢了冼生,祝愉快Thanks.
39、Thankyou,sir.Haveagoodday.机场快捷服务嘿Hey.妫:还好吗？Youokay?有收到我的留言吗？你的留言？Didyougetmymessages?Yourmessages?你开会开到一半突然跑掉Yousuddenlywalkoutofthemeeting而且没跟我说就直飞内布拉斯加州andflytoNebraskawithouttalkingtomeaboutit,你想留言有用吗？andyouthinkmessagesmakeitokay?抱歉我的天,约翰msorry.MyGod,John.我跟你一样想寻找奇迹,好吗？Iwannafindamiracleasmuchas
40、youdo,okay?但你怎么能拿工作开玩笑？Buthowcouldyouputyourjobinjeopardy?艾琳如果Aileen.Howexactly保险没了每个月四万元的医疗费要怎么付？dowepay$40,000amonthinhealthcareifyouloseyourinsurance?我不会失去工作的Honey,comeon.1.ook,mnotgonnalosemyjob.真的吗？0h,really?皮特昨晚打了两次电♥话♥来问你的状况Petecalledheretwicelastnighttoaskifyouwereokay.精神状况Youk
41、now,mentally.我会我会回电也会摆平这件事的lljust.llcall,andllsmooththatoneover.最好如此Yeah,noshit.我很抱歉msorry.我突然领悟到Somethinginmejustkindofsnapped.那晚在医院里当我们以为快失去她时Thatnightatthehospital,whenwethoughtthatwewerelosingher,我祈祷如果她时候到了Iprayedthatifitwashertime,就赶快走,不要忍♥受那么多苦shedgoquickly,withoutsomuchsuffering.但隔天早上,
42、她撑过来了Butmorningcame,andshepulledthrough.她的眼神Hereyes,如此坚决、勇敢sodetermined,sodefiant.充满奋斗力Thefightinher.这位叫史东希尔的家伙值得吗？Washeworthit?ThisStonehillguy?他很古怪但他的理论比其他人先进Hesreallyeccentric,buthisscienceiswayaheadofeverybodyelse,s.绝对值得我们投资只要我们有钱的话Hesdefinitelytheonetoputourmoneyon.1.fwehadany.我答应他,我们会募款1promis
43、edhimthatwedraisesome,因为下个月他会来这里开会becausehesgotthisconferenceupherenextmonth,我说过我会准备支票给他andIsaiddhaveacheckreadyforhim.多少？五十Howmuch?Fivehundred.就这样？万Thatsall?Thousand.是五十还是一万？Isit$500or$1,000?是五十万$500,000.下个月Bynextmonth.亲爰的,你疯了吗?显然是的Sweetheart,areyoutotallyinsane?Apparently.我们会在本月23日于学校举办第一次募款活动Were
44、holdingourfirstfundraiseronthe23rdattheschool,希望你和法兰克能参加andwewouldloveifyouandFrankcouldjoinus.准备好拼字测验了吗？好了Readyforyourspellingtest?mgonnanailit.祝好运Okay.Goodluck.我是奥勒岗州的约翰克劳利Myname,sJohnCrowley.mcallingfromOregon,我从亚特兰大区家有庞贝氏症儿协会得知您的andIgotyournamefromtheAtlanta-areaPompeparentsgroup.是的Yeah.很抱歉在同学会时
45、没见到你AndIwassosorrynottoseeyouatthereunion因为你是我高中时期最要好的朋友becauseyouwereoneofmymostfavoritepeopleinhighschool.总之,约翰和我在筹备这个基金会Anyway,JohnandIarestartingthisfoundation.嘿,爸?爸不,你懂我的意思Hey,Dad?Dad.No,youknowwhatImean.只是想改变情况Justmakeitright.爸？你没看到我在讲电♥话♥吗？Dad?Cantyouseemonthephone?好,告诉我他怎么说的爸！Okay,well,tellmewhathetoldyou.Dad!不,我再回你电♥话
