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1、,王理中,大数据时代的生命组学研究,“Traditional” VS “Modern” ways,Breakthrough of sequencing technologies,1st : Sanger 2nd : Illumina Solexa; Roche 454; ABI SOLID3rd : PacBio SMRT; Oxford Nanopore,Human Genome Project(HGP),30亿美元30亿个碱基对,The nations of the world must see that the human genome belongs to the worlds peo
2、ple, as opposed to its nations.- James D. Watson,The 1000 Genomes Project,The 1000 Genomes Project,All organisms have a genome,Plants&Animals,Tree of Life,Genome always be the initial understanding of a species,Life is complicated and systematic,中心法则 & Omics,ATCG,De novo genome,Comparative genomics,
3、Synteny analysis Gene family expansion and subtraction Diversity between species Genome rearrangement Chromosome fusion and fission Ultra conserved elements Accelerative evolving regions Phylogenomics,Gene expansion in the yak genomesensory perception energy metabolism,Population genomics,Wild yak,D
4、omestic yak, log-ratio0.65 and FST 0.17182 regions (14.5Mb, 0.54% of the genome)209 genes,Overrepresented GO:Regulation of transmission of nerve impulse (GO:0051969)Arc, ASPA, ATP2B2, MYO6, NTRK2, Rab40c, SNCA, and TG,30 genes involved in Neurogenesis and behavior,Only a few genes subject to physica
5、l characteristics and economically significant traits,Early Domestication StageA trade-off between survival of yaks in a harsh high-altitude environment and performance under pastoral conditions,Domestication of yak,Human colonization in QTP,Present,Metagenomics,Epigenomics,Twins,Expression regulationGenomic imprintingTissue specific gene expressionDiseases related,Transcriptome,Proteome & Metabolome,Sequencing Costs and Development,Ten highest-grossing drugs in the USA fail to improve the conditions of people(Do help and fail to help),From Science to Application,Thank you!,
