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1、OECD GUIDELINES FOR TESTING OF CHEMICALSFull List of Test GuidelinesJuly 2015SECTION 1 - PHYSICAL-CHEMICAL PROPERTIESSummary of Considerations in the Report from the OECD Expert Group on Physical ChemistryNo.TitleOriginal AdoptionNo. of UpdatesUpdatesMost recent update101UV-VIS Absorption Spectra12
2、May 19810-102Melting Point/Melting Range12 May 1981127 July 1995103Boiling Point12 May 1981127 July 1995104Vapour Pressure12 May 1981227 July 199523 March 2006105Water Solubility12 May 1981127 July 1995106Adsorption/Desorption Using a Batch Equilibrium Method12 May 1981121 January 2000107Partition C
3、oefficient (n-octanol/ water): Shake Flask Method12 May 1981127 July 1995108Complex Formation Ability in Water12 May 19810-109Density of Liquids and Solids12 May 1981227 July 19952 October 2012110Particle Size Distribution/Fibre Length and Diameter Distributions12 May 19810-111Hydrolysis as a functi
4、on of pH12 May 1981113 April 2004112Dissociation Constants in Water12 May 19810-113Screening Test for Thermal Stability and Stability in Air12 May 19810-114Viscosity of Liquids12 May 198112 October 2012115Surface Tension of Aqueous Solutions12 May 1981127 July 1995116Fat Solubility of Solid and Liqu
5、id Substances12 May 19810-117Partition Coefficient (n-octanol/water), HPLC method30 March 1989113 April 2004118Determination of the Number-Average Molecular Weight and the Molecular Weight Distribution of Polymers using Gel Permeation Chromatography14 June 19960-119Determination of the Low Molecular
6、 Weight Content of a Polymer Using Gel Permeation Chromatography14 June 19960-120Solution/Extraction Behaviours of Polymers in Water14 June 1996121 January 2000121Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC) 22 Januar
7、y 20010-122Determination of pH, Acidity and Alkalinity26 July 20130-123Partition Coefficient (1-Octanol / Water): Slow-Stirring Method23 March 20060-SECTION 2 - EFFECTS ON BIOTIC SYSTEMSSummary of Considerations in the Report from the OECD Expert Group on EcotoxicologyNo.TitleOriginal AdoptionNo. of
8、 UpdatesUpdatesMost Recently Updated201Freshwater Alga and Cyanobacteria, Growth Inhibition Test12 May 198127 June 198423 March 2006(corrected on 28July 2011)202Daphnia sp. Acute Immobilisation Test12 May 1981(adopted as Daphnia sp.14-day Reproduction Test including an Acute Immobilisation Test)24 A
9、pril 198413 April 2004203Fish, Acute Toxicity Test12 May 198124 April 198417 July 1992204Fish, Prolonged Toxicity Test: 14-Day Study4 April 19840Date of deletion2 April 2014205Avian Dietary Toxicity Test4 April 19840-206Avian Reproduction Test4 April 19840-207Earthworm, Acute Toxicity Tests4 April 1
10、9840-208Terrestrial Plants, Growth Test4 April 1984119 July 2006209Activated Sludge, Respiration Inhibition Test (Carbon and Ammonium Oxidation)4 April 1984122 July 2010210Fish, Early-Life Stage Toxicity Test17 July 1992126 July 2013211Daphnia magna Reproduction Test21 September 199823 October 20082
11、 October 2012212 Fish, Short- term Toxicity Test on Embryo and Sac-fry Stages21 September 19980-213Honeybees, Acute Oral Toxicity Test21 September 19980-No.TitleOriginal AdoptionNo. of updatesUpdatesMost recent update214Honeybees, Acute Contact Toxicity Test21 September 19980-215Fish, Juvenile Growt
12、h Test21 January 20000-216Soil Microorganisms: Nitrogen Transformation Test21 January 20000-217Soil Microorganisms: Carbon Transformation Test21 January 20000-218Sediment-Water Chironomid Toxicity Using Spiked Sediment13 April 20040-219Sediment-Water Chironomid Toxicity Using Spiked Water13 April 20
13、040-220Enchytraeid Reproduction Test13 April 20040-221Lemna sp. Growth Inhibition Test23 March 20060-222Earthworm Reproduction Test (Eisenia fetida/Eisenia andrei)13 April 20040-223Avian Acute Oral Toxicity Test22 July 20100-224Determination of the activity of anaerobic bacteria Reduction of gas pro
14、duction from anaerobically sewage sludge8 January 20070-225Sediment-Water Lumbriculus Toxicity Test Using Spiked Sediment16 October 20070-No.TitleOriginal AdoptionNo. of updatesUpdatesMost recent update226Predatory Mite (Hypoaspis (Geolaelaps) Aculeifer) Reproduction Test in Soil3 October 20080-227T
15、errestrial Plant Test: Vegetative Vigour Test19 July 20060-228Determination of Developmental Toxicity of a Test Chemical to Dipteran Dung Flies (Scathophaga stercoraria L. (Scathophagidae) and Musca automnalis De Geer (Muscidae)3 October 20080-229Fish Short Term Reproduction Assay7 September 200912
16、October 201223021-Day Fish Assay: AShort Term Screening Assay for Oestrogenic and Androgenic Activity, and Aromatase Inhibition7 September 20090-231Amphibian Metamorphosis Assay7 September 20090-232Collembolan Reproduction Test in Soil7 September 20090-233Sediment-Water Chironomid Life-Cycle Toxicit
17、y Test Using Spiked Water or Spiked Sediment22 July 20100-234Fish Sexual Development Test28 July 20110-235Chironomus sp., Acute Immobilisation Test28 July 20110-236Fish Embryo Acute Toxicity (FET) Test26 July 20130-No.TitleOriginal AdoptionNo. of updatesUpdatesMost recent update237Honey bee (Apis me
18、llifera) Larval Toxicity Test, Single Exposure26 July 20130-238Sediment-free Myriophyllum spicatum Toxicity Test 26 September 20140-239Water-Sediment Myriophyllum spicatum Toxicity Test26 September 20140-240Medaka Extended One-Generation Reproduction Test28 July 20150-241Larval Amphibian Growth and
19、Development Assay28 July 20150-SECTION 3 DEGRADATION AND ACCUMULATIONSummary of Considerations in the Report from the OECD Expert Group on Degradation/AccumulationNo.TitleOriginal AdoptionNo. of UpdatesUpdatesMost Recently Updated301Ready Biodegradability: 301A : DOC Die-Away Test301B : CO2 Evolutio
20、n Test301C : Modified MITI Test (I)301D : Closed Bottle Test301E : Modified OECD Screening Test301F : Manometric Respirometry Test12 May 1981117 July 1992(301F corrected on 26July 2013)302AInherent Biodegradability: Modified SCAS Test12 May 19810-302BInherent Biodegradability: Zahn-Wellens/EMPA Test
21、12 May 1981117 July 1992302CInherent Biodegradability: Modified MITI Test (II)12 May 19810(corrected in 2009)303Simulation Test Aerobic Sewage Treatment: A:Activated Sludge Units; B:Biofilms12 May 1981122 January 2001304AInherent Biodegradability in Soil12 May 19810-305Bioaccumulation in Fish: Aqueo
22、us and Dietary Exposure12 May 1981214 June 19962 October 2012306Biodegradability in Seawater17 July 19920-307Aerobic and Anaerobic Transformation in Soil24 April 20020-308Aerobic and Anaerobic Transformation in Aquatic Sediment Systems24 April 20020-309Aerobic Mineralisation in Surface Water Simulat
23、ion Biodegradation Test13 April 20040310Ready Biodegradability CO2 in sealed vessels (Headspace Test)23 March 20060(corrected on 26September 2014)No.TitleOriginal AdoptionNo. of UpdatesUpdatesMost Recently Updated311Anaerobic Biodegradability of Organic Compounds in Digested Sludge: by Measurement o
24、f Gas Production23 March 20060-312Leaching in Soil Columns13 April 20040-313Estimation of Emissions from Preservative - Treated Wood to the Environment: Laboratory Method for Wooden Commodities that are not Covered and are in Contact with Fresh Water or Seawater16 October 20070-314Simulation Tests t
25、o Assess the Biodegradability of Chemicals Discharged in Wastewater3 October 20080-315Bioaccumulation in Sediment-dwelling Benthic Oligochaetes3 October 20080-316Phototransformation of Chemicals in Water- Direct Photolysis3 October 20080-317Bioaccumulation in Terrestrial Oligochaetes22 July 20100-SE
26、CTION 4 HEALTH EFFECTSSummary of Considerations in the Report from the OECD Expert Groups on Short and Long Term ToxicologyNo.TitleOriginal AdoptionNo. of UpdatesUpdatesMost Recently Updated401Acute Oral Toxicity12 May 1981124 February 1987Date of Deletion: 17 December 2001402Acute Dermal Toxicity12
27、 May 1981124 February 1987403Acute Inhalation Toxicity12 May 198117 September 2009404Acute Dermal Irritation/ Corrosion12 May 1981317 July 199224 April 200228 July 2015405Acute Eye Irritation/ Corrosion12 May 1981324 April 200224 Feb. 19872 October 2012406Skin Sensitisation12 May 1981117 July 199240
28、7Repeated Dose 28-Day Oral Toxicity Study in Rodents12 May 1981227 July 19953 October 2008408Repeated Dose 90-Day Oral Toxicity Study in Rodents12 May 1981121 September 1998409Repeated Dose 90-Day Oral Toxicity Study in Non-Rodents12 May 1981121 September 1998410Repeated Dose Dermal Toxicity:90-Day1
29、2 May 19810-411Subchronic Dermal Toxicity: 90-day Study12 May 19810-412Subacute Inhalation Toxicity: 28-Day Study12 May 198117 September 2009413Subchronic Inhalation Toxicity: 90-Day Study12 May 198117 September 2009414Prenatal Developmental Toxicity Study12 May 1981122 January 2001415One-Generation
30、 Reproduction Toxicity Study26 May 19830-416Two-Generation Reproduction Toxicity Study26 May 1983122 January 2001417Toxicokinetics4 April 1984122 July 2010418Delayed Neurotoxicity of Organophosphorus Substances Following Acute Exposure 4 April 1984127 July 1995419Delayed Neurotoxicity of Organophosp
31、horus Substances: 29-Day Repeated Dose Study4 April 1984127 July 1995420Acute Oral toxicity Fixe Dose Procedure17 July 1992117 December 2001421Reproduction/Developmental Toxicity Screening Test27 July 1995128 July 2015422Combined Repeated Dose Toxicity Study with the Reproduction/ Developmental Toxi
32、city Screening Test22 March 1996128 July 2015423Acute Oral Toxicity Acute Toxic Class Method22 March 1996117 December 2001424Neurotoxicity Study in Rodents21 July 19970-425Acute Oral Toxicity: Up-and-Down Procedure21 September 1998217 December 200123 March 2006 (corrected on 3October 2008)426Develop
33、mental Neurotoxicity Study16 October 20070-427Skin Absorption: in vivo Method13 April 2004-428Skin Absorption: in vitro Method13 April 2004-429Skin Sensitisation: Local Lymph Node Assay24 April 2002122 July 2010430in vitro Skin Corrosion: Transcutaneous Electrical Resistance Test (TER)13 April 20042
34、26 July 201328 July 2015431in vitro Skin Corrosion: Reconstructed Human Epidermis (RHE) Test13 April 2004326 July 201326Sept. 201428 July 2015432in vitro 3T3 NRU Phototoxicity Test13 April 20040-435in vitro Membrane Barrier Test Method for Skin Corrosion19 July 2006128 July 2015436Acute Inhalation T
35、oxicity - Acute Toxic Class Method7 September 20090-437Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants7 September 2009(corrected in 2010)126 July 2013 438Isolated Chicken Eye Test Method for Identifying Ocular Corrosives and Severe Irritants
36、7 September 2009126 July 2013439in vitro Skin Irritation: Reconstructed Human Epidermis Test Method22 July 2010226 July 201328 July 2015440Uterotrophic Bioassay in Rodents: A short-term screening test for oestrogenic properties16 October 20070-441Hershberger Bioassay in Rats: A short-term Screening
37、Assay for (Anti)Androgenic Properties7 September 20090-442ASkin Sensitization: Local Lymph Node Assay: DA22 July 20100-442BSkin Sensitization: Local Lymph Node Assay: BrdU-ELISA22 July 20100-442CIn chemico skin Sensitisation5 February 20150-442DIn vitro Skin Sensitisation5 February 20150-443Extended
38、 One-Generation Reproductive Toxicity Study28 July 2011 0(Corrected on 2October 2012)451Carcinogenicity Studies12 May 198117 September 2009452Chronic Toxicity Studies12 May 198117 September 2009453Combined Chronic Toxicity/ Carcinogenicity Studies12 May 198117 September 2009455Performance-based Test
39、 Guideline for Stably Transfected Transactivation in vitro Assays to Detect Estrogen Receptor Agonists and Antagonists7 September 200922 October 201228 July 2015456H295R Steroidogenesis Assay28 July 20110-457BG1Luc Estrogen Receptor Transactivation in vitro Assay to Detect Estrogen Receptor Agonists
40、 and Antagonists2 October 20120460Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe Irritants2 October 20120Introduction to the OECD Test Guidelines on genetic toxicology testing and guidance on the selection and application of assaysNo.TitleOriginal AdoptionNo. of Updates
41、UpdatesMost Recently Updated471Bacterial Reverse Mutation Test26 May 1983121 July 1997472Genetic Toxicology: Escherichia coli, Reverse Assay26 May 19830Date of deletion:21 July 1997(Method merged with TG471)473in vitro Mammalian Chromosome Aberration Test26 May 1983221 July 199726September 2014474in
42、 vivo Mammalian Erythrocyte Micronucleus Test26 May 1983221 July 199726September 2014475in vivo Mammalian Bone Marrow Chromosome Aberration Test4 April 1984221 July 199726September 2014476in vitro Mammalian Cell Gene Mutation Test4 April 1984221 July 199728 July 2015477Genetic Toxicology: Sex-Linked
43、 Recessive Lethal Test in Drosophilia melanogaster4 April 19840Date of deletion2 April 2014478Genetic Toxicology: Rodent Dominant Lethal Test4 April 1984128 July 2015479Genetic Toxicology: in vitro Sister Chromatid Exchange assay in Mammalian Cells23 October 19860Date of deletion2 April 2014480Genetic Toxicology:
