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1、抑郁症研究的动物模型,基础01级 陈瑶瑶,I am depressed.Me too.,Why we need animal models?The sorts of animal models.The future development of animal models.,The uses of animal models,Antidepressants screening.Mechanism studying,神经生化功能改变模型应激模型 条件性饲养模型 基因工程动物模型,获得性无助模型(learned helpless)慢性温和应激模型(chronic mild stress)行为绝望模
2、型(behavioral despair),Gene-engineering mice,Conventional transgenic miceConditional gene-targeting methodsAntisense targeting,展望,实验动物模型是研究抑郁症必不可少的工具。随着基因工程技术的出现，实验模型的可操作性和多样性都大大改善了。虽然转基因技术仍存在很多问题，但其仍有着光明的前景。,Reference_1Janne Grnli a,.,Robert Murison b,d,Bjrn Bjorvatn c,d,Eli Srensen a,Chiara M.Porta
3、s a,Reidun Ursin a,d，Chronic mild stress affects sucrose intake and sleep in rats，Behavioural Brain Research 150(2004)1391472John F.Cryan,Daniel Hoyer,and Athina Markou，Withdrawal from Chronic Amphetamine Induces Depressive-Like Behavioral Effects in Rodents，BIOL PSYCHIATRY 2003;54:49583Andrew Harki
4、n*,John P.Kelly,Brian E.Leonard，A review of the relevance and validity of olfactory bulbectomy as a model of depression，Clinical Neuroscience Research 3(2003)2532624.Vijayakumar Mavanjia,b,Subimal Dattaa,*，Clomipramine treatment in neonatal rats alters the brain acetylcholinesterase activity in adul
5、thood，Neuroscience Letters 330(2002)1191215.Ruth E.Grahn a,*,S.E.Hammack a,M.J.Will b,K.A.OConnor a,T.Deak c,P.D.Sparks a,L.R.Watkins a,S.F.Maier a,Blockade of alpha1 adrenoreceptors in the dorsal raphe nucleus prevents enhanced conditioned fear and impaired escape performance following uncontrollab
6、le stressor exposure in rats,Behavioural Brain Research 134(2002)387_/3926.Peter Gassa,*,Holger M.Reichardtb,Tatyana Strekalovaa,Fritz Henna,Francois Troncheb,Mice with targeted mutations of glucocorticoid and mineralocorticoid receptors:Models for depression and anxiety?Physiology 52:503528,10Overm
7、ier JB,Seligman ME.Effects of inescapable shock upon subsequent escape and avoidance responding.J Comp Physiol Psychol 1967;63:2833.neurotransmitter release in an animal model of depression.Neurochem Int 1992;21:2935.11Barbara Vollmayr*,Fritz A.Henn，Stress models of depression，Clinical Neuroscience
8、Research 3(2003)24525112Katz RJ,Schmaltz K.Dopaminergic involvement in attention.A novel animal model.Prog Neuropsychopharmacol 1980;4:58590.Psychopharmacology13Willner P,Towell A,Sampson D,Sophokleous S,Muscat R.Reduction of sucrose preference by chronic unpredictable mild stress and its restoratio
9、n by a tricyclic antidepressant.Psychopharmacology(Berl)1987;93:35864.14Willner P,Muscat R,Papp M.Chronic mild stress-induced anhedonia:a realistic animal model of depression.Neurosci Biobehav Rev 1992;16:52534.15许晶,李晓秋，慢性应激抑郁模型的建立及其评价，Chinese Journal of Behavioral Medical Science 12(1),200316.Morea
10、u JL,Scherschlicht R,Jenck F,Martin JR.Chronic mild stress induced anhedonia model of depression;sleep abnormalities and curative effects of electroshock treatment.Behav Pharmacol 1995;6:6827.17吕俊华,钟玲，实验性抑郁症动物模型的评价，中国病理生理杂志Chinese Journal of Pathophysiology2001,17(9):916-91918.John F.Cryan,Athina Markou and Irwin Lucki，Assessing antidepressant activity in rodents:recent developments and future needs TRENDS in Pharmacological Sciences Vol.23 No.5 May 200219.郭建友，李昌煜，葛卫红,抑郁症动物模型研究进展,中国临床康复第第八卷第10期,感谢：,肖远、陈怡、刘婷婷、王颖、李逸、阎焰、平星杰（排名不分先后）感谢她们在本次讨论中的积极参与；感谢王昕老师老师给我们这次机会；感谢在座各位老师和同学给予的耐心。,
