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1、1,基本检索技巧-如何利用主题词在CAplus中查找信息,2,什么是STN联机前的准备工作在线操作,内 容,3,STN-The Scientific&Technical Information Network,由美国化学文摘社(CAS)和德国卡尔斯鲁厄(FIZ Karlsruhe)经营,日本科技情报中心(JICST)在日本代理收录超过200个科学和技术数据库，涵盖了广泛的学科 完整的CAS的数据库 CAplus,CA Registry,CASREACT,MARPAT 重要的专利数据库 DWPISM,INPADOCDB,EPFULL,BIOSIS,USPATFULL/USPAT2,PCTFULL
2、,and more用先进的计算机语言访问,显示和可视化数据库中的信息,4,STN检索界面,STN有以下三种访问方式：a.STN on the Web b.STN Expressc.STNEasy STN on the Web和STN Express都是指令检索界面，其检索功能完全一样，区别在于STN on the web是通过网页访问，而STN Express是通过客户端访问。STNEasy采用的是对话框似的访问方式，无需使用指令，操作方法简单，因此不能达到对文献检索精而全的要求。,STN检索界面,5,STN中可使用的指令,在STN中，可用的指令超过20个,其中，第一列是最常用的5个指令,ST
3、N中可使用的指令,STN中可使用的指令,6,联机前的准备工作,7,联机前的准备工作确定要查找的关键词查找同义词、不同拼写方式和缩写使用合适的截词符使用合适的连接符,8,同一主题的文献，作者有可能使用不同的同义词和缩写一些了解同义词、缩写的方法和同事讨论做一次初次检索在得到的记录中寻找替代词使用在线词典或词库(将在高级检索技巧中讨论)尝试一些网站,e.g.http:/http:/,查找同义词和缩写词,9,使用合适的截词符,使用截词符可以检索到包含相同一组字母的词语。从而做到省钱和省时STN中的截词符号有,使用合适的截词符,10,在字/词间使用合适的连接符,在STN中，使用的连接符有：,11,练
4、习,请确定下面检索问题的主要概念及其同义词，并用合适的连接符建立检索式 检索问题:1.Method to analyze heavy metals in wastewater from gold mine tailings.2.Understanding the links between human chromosomes and the onset of diabetes in old patients,12,题1的主要关键词及其同义词：heavy metals:wastewater:sewage,wash water,effluent,waste liqs,drainage gold:a
5、urum tailing:S heavy(a)metals 后得到L1S wastewater(or)sewage(or)wash water(or)effluent(or)waste liqs(or)drainage 得到L2S Gold(or)aurum 得到L3S tail？得到L4S L1 AND L2 AND L3 AND L4题2的主要关键词及其同义词及其同义词？Chromosomes:Diabetes:Old patients:,13,在线操作,14,以例子说明在CAplus中查询主题词的步骤,15,CAplus 简介,CAplus收录了150多个国家的约10000万多种期刊及5
6、0个国家和两个专利组织的专利，最早的文献可以回溯到1840年涵盖的学科包括应用化学、化学工程、有机化学、生物化学、物理化学、无机化学和分析化学CAplus中的记录包含有题录信息、摘要和主题及物质索引等,16,CAplus中收录的文献种类的比例,17,CAplus中的一篇记录,了解数据库内容的一个很好方法就是仔细查看它的记录,ACCESSION NUMBER:1998:137530 CAPLUS Full-textDOCUMENT NUMBER:128:221420ENTRY DATE:Entered STN:09 Mar 1998TITLE:UV damage on human hair.A
7、comparison study of 10 UV filtersAUTHOR(S):Gonzenbach,H.;Johncock,W.;De Polo,K.-F.;Blankenburg,G.;Fohles,J.;Schafer,K.;Hocker,H.CORPORATE SOURCE:Roche Vitamins and Fine Chemicals,Geneva,Switz.SOURCE:Cosmetics ISSN:0361-4387PUBLISHER:Allured Publishing Corp.DOCUMENT TYPE:JournalLANGUAGE:EnglishCLASSI
8、FICATION:62-3(Essential Oils and Cosmetics)ABSTRACT:UV-induced alterations in virgin blond Caucasian hair and in virgin black Asian hair were assessed in a preliminary study by measuring color changes,mech.properties(single hair friction,combing force and tensile strength),FTIR spectroscopy and clas
9、sical amino-acid anal.The amino-acid anal.seemed the most sensitive test.Next,virgin blond Caucasian hair were treated with 10 protective test formulations and exposed each to simulated sunlight.The different results can be attributed to qual.differences in deposition induced by the formulation.,原始文
10、献有7页,作者所写,简写,18,CAplus中的一篇记录,接上页),SUPPL.TERM:UV damage hair filter amino acidINDEX TERM:Hair preparations(creams;study of UV damage on human hair)INDEX TERM:Hair preparations Hair preparations(emulsions;study of UV damage on human hair)INDEX TERM:Shampoos Sunscreens(study of UV damage on human hair)
11、INDEX TERM:Amino acids,analysis ROLE:ANT(Analyte);ANST(Analytical study)(study of UV damage on human hair)INDEX TERM:56-89-3,Cystine,analysis 60-18-4,Tyrosine,analysis 73-22-3,Tryptophan,analysis 498-40-8,Cysteic acid ROLE:ANT(Analyte);ANST(Analytical study)(study of UV damage on human hair),索引词,索引副
12、标题,CAS Registry Numbers(物质的系统编码),CAS Role(物质的详细信息),19,CAplus中的检索字段,其最常用检索字段：,注：CAplus中有39个常用检索字段，具体信息请见STN Database Summary http:/,20,CAplus中的检索字段,如果只查找专利，则其最常用检索字段有：,注：CAplus中有53个字段供检索专利，具体信息请见STN Database Summary http:/,21,检索步骤,运用主题词在CAplus中检索文献的步骤,22,检索步骤,运用主题词在CAplus中检索文献的步骤,检索步骤,23,检索问题:What ha
13、s been reported on the antitumor activity of antibiotics derived or produced from Streptomyces bacteria?,24,第一步：确定关键的主题词,25,第二步:确定关键词语的同义词或缩写,Antitumor：anticancer,antineoplastic,antitumour,anti-tumorAntibiotics:immue,resistant,26,进行初步检索有助于帮助我们决定检索策略是否正确在初步检索时，将连续用到三个基本指令,第三步：进行初步检索,27,运用FILE指令进入数据库,
14、=FILE CAPLUSFILE CAPLUS ENTERED AT 20:34:16 ON 24 OCT 2006USE IS SUBJECT TO THE TERMS OF YOUR STN CUSTOMER AGREEMENT.PLEASE SEE HELP USAGETERMS FOR DETAILS.COPYRIGHT(C)2006 AMERICAN CHEMICAL SOCIETY(ACS)Copyright of the articles to which records in this database refer isheld by the publishers listed
15、 in the PUBLISHER(PB)field(available of this information,without the prior written consent of CAS,isstrictly prohibited.FILE COVERS 1907-23 Jul 2009 VOL 151 ISS 4FILE LAST UPDATED:22 Jul 2009(20090722/ED)This file contains CAS Registry Numbers for easy and accurate substance identification.Effective
16、 October 17,2005,revised CAS Information Use Policies apply.They are available for your review at:http:/,第三步A:进入数据库,进入数据库后有数据库的基本信息，包括更新及数据库覆盖年代等信息,28,运用EXPAND指令确定要查的词语是否在数据库中存在当运用主题词查询时，使用EXPAND非常有用 确定在数据库里是否存在该词 确定词语的不同拼写形式（需用哪个截词符）通过EXPAND，可以获得与检索词相近的词语列表，就象打开了一本字典,第三步B:确定检索词,29,=SET EXPAND CONTI
17、NUOUSSET COMMAND COMPLETED=E ANTITUMORE1 1 ANTITUMOOR/BIE2 1 ANTITUMOPR/BIE3 287132-ANTITUMOR/BIE4 1 ANTITUMORACTIVITY/BIE5 1 ANTITUMORAGENTS/BIE6 2360 ANTITUMORAL/BIE7 1 ANTITUMORALE/BIE8 1 ANTITUMORALEN/BIE9 1 ANTITUMORALER/BIE10 3 ANTITUMORALLY/BIE11 19 ANTITUMORALS/BIE12 1 ANTITUMORAND/BI=EE13 1
18、 ANTITUMORCANCER/BIE14 3 ANTITUMORGENIC/BIE15 1 ANTITUMORGENICITY/BIE16 1 ANTITUMORGENICS/BI E21 32 ANTITUMORIGENESIS/BIE22 476 ANTITUMORIGENIC/BIE23 11 ANTITUMORIGENICITY/BIE24 1 ANTITUMORIMMUNOPOTENCY/BI,第三步B:确定检索词,30,第三步B:确定检索词,E anticancer E37 1 ANTICANATOXIN/BI E38 1 ANTICANCE/BI E39 58673-ANTI
19、CANCER/BI E40 1 ANTICANCERACUTE/BI E41 2 ANTICANCERAL/BI E47 6 ANTICANCERIGENIC/BI E48 1 ANTICANCERLIN/BI=E immune E85 1 IMMUNDOMINANT/BI E86 1 IMMUNDUS/BI E87 262389-IMMUNE/BI E88 2 IMMUNEACTIVE/BI E94 1 IMMUNEASSOCD/BI E95 1 IMMUNEASY/BI E96 1 IMMUNEBODIES/BI,31,=E ANTIBIOTICE97 27 ANTIBIOTHERAPY/
20、BIE98 1 ANTIBIOTI/BIE99 101225-ANTIBIOTIC/BIE100 2 ANTIBIOTIC8907/BIE101 44 ANTIBIOTICA/BIE102 5 ANTIBIOTICAL/BIE103 199 ANTIBIOTICALLY/BIE104 1 ANTIBIOTICAS/BI E105 1 ANTIBIOTICCOMBNS/BIE106 2 ANTIBIOTICCS/BI=E STREPTOMYCESE107 1 STREPTOMYCER/BIE108 1 STREPTOMYCERS/BIE109 30604-STREPTOMYCES/BIE110
21、1 STREPTOMYCESA/BIE111 1 STREPTOMYCESAUREOFACIENS/BIE112 1 STREPTOMYCESERYTHREUS/BI E113 1 STREPTOMYCESROSEOFLAVUS/BIE114 5 STREPTOMYCESS/BIE115 1 STREPTOMYCESSP/BI,第三步B:确定检索词,32,通过EXPAND可以发现词语的不同拼写形式运用词语的不同拼写形式将使检索信息非常全面 有两种方式能将这些不同拼写形式的词语组合在一起:STN指令设置 截词符,第三步C:建立检索式,33,自动设置 使用指令SET PLURALS ON，STN可
22、以自动检索到词语的单复数形式使用指令SET ABB ON，STN可以自动检索到词语的缩写形式使用指令SET SPELLINGS ON，STN可以自动检索到词语的英美不同拼写形式,第三步C:建立检索式,34,使用截词符运用截词符能够检索到词语的:单/复数前缀和后缀 词语的英/美拼写形式,第三步C:建立检索式,35,第三步C:建立检索式,请使用合适的截词符，确保能同时检索到下面的词语 antitumor,antitumorigenic,antitumorigenically,antitumorigenicity,antitumoral(antitumor?)antibiotic,antibioti
23、cs(antibiotic#),第三步C:建立检索式,36,使用 SEARCH检索目标记录,=SET ABB ONSET COMMAND COMPLETED=SET PLURALS ONSET COMMAND COMPLETED=SET SPELLINGS ONSET COMMAND COMPLETED=s(antitumor?or anticancer?)and(antibiotic#or immune)and e109 288258 ANTITUMOR?58921 ANTICANCER?199139 ANTIBIOTIC#262389 IMMUNE 11 IMMUNES 262393 IM
24、MUNE(IMMUNE OR IMMUNES)39521 STREPTOMYCES/BIL1 1365(ANTITUMOR?OR ANTICANCER?)AND(ANTIBIOTIC#OR IMMUNE)AND STRE PTOMYCES/BI,第三步D:运行检索,37,运用 D SCAN 评估初步检索结果，其目的在于：确定结果是否是你想要的 查看数据库中是否有其他可用的特定技术用语 它是免费的运用D SCAN 将从结果集中随机显示答案（在CAplus中，其只显示标题和索引信息）,第四步:评价结果,第四步:评估结果,38,=D SCANL1 1191 ANSWERS CAPLUS COPYRI
25、GHT 2006 ACSIC ICM C12P019-56 ICS C07H015-252;A61K031-71CC 16-2(Fermentation and Bioindustrial Chemistry)TI IT-62-B substance and medicinal composition containing the sameST neoplasm inhibitor IT62B Streptomyces fermn;antibiotic IT62B fermn Streptomyces IT Antibiotics Fermentation Neoplasm inhibitor
26、s Streptomyces(antitumor antibiotic IT-62-B from Streptomyces)IT Neoplasm inhibitors(nasopharynx,antitumor antibiotic IT-62-B from Streptomyces)IT Pharynx(nasopharynx,neoplasm,inhibitors,antitumor antibiotic IT-62-B from Streptomyces)IT 176259-62-4P,Antibiotic IT 62B RL:BPN(Biosynthetic preparation)
27、;THU(Therapeutic use);BIOL(Biological study);PREP(Preparation);USES(Uses)(antitumor antibiotic IT-62-B from Streptomyces)HOW MANY MORE ANSWERS DO YOU WISH TO SCAN?(1):1,第四步:评估结果,39,L1 1191 ANSWERS CAPLUS COPYRIGHT 2006 ACSIC ICM C12P001-06 ICS A61K035-74;C07G017-00;C12P001-06;C12R001-465CC 16-2(Ferm
28、entation and Bioindustrial Chemistry)Section cross-reference(s):1,63TI Manufacture of NA22598B1 and NA22598B2 as anticancer agents,and their manufacture with Streptomyces speciesST anticancer NA22598B1 NA22598B2 manuf Streptomyces IT Antitumor agents(antibiotic;manufacture of NA22598B1 and NA22598B2
29、 as anticancer agents with Streptomyces sp.)IT Antibiotics(antitumor;manufacture of NA22598B1 and NA22598B2 as anticancer agents with Streptomyces sp.)IT Fermentation Streptomyces(manufacture of NA22598B1 and NA22598B2 as anticancer agents with Streptomyces sp.)IT 226900-64-7P,NA 22598B1 226900-71-6
30、P,NA 22598B2 RL:BAC(Biological activity or effector,except adverse);BMF(Bioindustrial manufacture);BPN(Biosynthetic preparation);BSU(Biological study,unclassified);PRP(Properties);THU(Therapeutic use);BIOL(Biological study);PREP(Preparation);USES(Uses)(manufacture of NA22598B1 and NA22598B2 as antic
31、ancer agents with Streptomyces sp.)HOW MANY MORE ANSWERS DO YOU WISH TO SCAN?(1):1,第四步:评估结果,40,L1 1191 ANSWERS CAPLUS COPYRIGHT 2006 ACSIC ICM C07C065-36 ICS A61K031-194;A61P031-04;A61P035-00;C12N001-20;C12P007-50;C12R001-465CC 16-2(Fermentation and Bioindustrial Chemistry)Section cross-reference(s)
32、:1,10,63TI Novel polycyclic compound,TEL68M,its fermentative manufacture,and its use as antibacterial and antitumor agentsST antibacterial antitumor TEL68M manuf Streptomyces IT Antitumor agents(antibiotic;manufacture of TEL68M as antibacterial and antitumor agents with Streptomyces sp.)IT Antibioti
33、cs(antitumor;manufacture of TEL68M as antibacterial and antitumor agents with Streptomyces sp.)IT Antibiotics Fermentation New natural products Streptomyces(manufacture of TEL68M as antibacterial and antitumor agents with Streptomyces sp.)(下页继续),第四步:评估结果,41,IT 343782-05-8P RL:BAC(Biological activity
34、 or effector,except adverse);BMF(Bioindustrial manufacture);BPN(Biosynthetic preparation);BSU(Biological study,unclassified);THU(Therapeutic use);BIOL(Biological study);PREP(Preparation);USES(Uses)(manufacture of TEL68M as antibacterial and antitumor agents with Streptomyces sp.)HOW MANY MORE ANSWER
35、S DO YOU WISH TO SCAN?(1):1L1 11916 ANSWERS CAPLUS COPYRIGHT 2006 ACSCC 74(Fermentations)TI Production of antitumor antibiotics of the encalin group by actinomycetesIT Antibiotic substances(encaline group,from Streptomyces)HOW MANY MORE ANSWERS DO YOU WISH TO SCAN?(1):0,第四步:评估结果,42,第五步:调整检索策略,用主题词检索
36、时，常因不同的人员会有不同的结果 通常，可以使用更宽泛的词语使检索更全面或者使用更确定的词语使检索更精确初级检索后需要考虑的问题有:这些结果是你需要的吗？大部分的结果都是相关的吗？是否可以接受结果数?,43,第五步:调整检索策略,将采用什么方法？,44,第五步:调整检索策略,添加可替代的词语,45,检索更完整的查询,=S(ANTITUMOR?OR ANTITUMOUR?OR ANTI-TUMOR?OR ANTICANCER?OR NEOPLASM INHIBIT?)L2 265344(ANTITUMOR?OR ANTITUMOUR?OR ANTI-TUMOR?OR ANTICANCER?OR
37、NEOPLASM INHIBIT?)=S(ANTIBIOTIC#OR ANTIBACTER?)L3 238537(ANTIBIOTIC#OR ANTIBACTER?)=S(STREPTOMYCES OR ACTINOMYCETES)L4 40479(STREPTOMYCES OR ACTINOMYCETES)=S L2 AND L3 AND L4L5 1608 L2 AND L3 AND L4,第五步:调整检索策略,46,第五步:调整检索策略,47,=S L2(S)L3(S)L4L6 808 L2(S)L3(S)L4,第五步:调整检索策略,用使结果更精确的连接符连接检索词,48,=D SCAN
38、 HITL6 808 ANSWERS CAPLUS COPYRIGHT 2006 ACSTI Studies on the isotetracenone antibiotics.II.Kerriamycins A,B and C,new antitumor antibioticsTI Studies on the isotetracenone antibiotics.II.Kerriamycins A,B and C,new antitumor antibioticsIT Antibiotics(from Streptomyces violaceolatus,kerriamycins as)I
39、T Neoplasm inhibitors(kerriamycins)IT Streptomyces violaceolatus(kerriamycins from)HOW MANY MORE ANSWERS DO YOU WISH TO SCAN?(1):1,第五步:调整检索策略,评估新的检索结果,49,L6 808 ANSWERS CAPLUS COPYRIGHT 2006 ACSTI Novel antibiotics,K93-0711-R4 and K93-0711-R6,and their manufacture with Streptomyces speciesST antican
40、cer antibiotic K930711R manuf Streptomyces;adriamycin resistant P388 leukemia inhibition K930711RIT Antitumor agents(antibiotic;manuf.of antibiotic K93-0711-R4 and K93-0711-R6 with Streptomyces sp.for inhibition of adriamycin-resistant P388 leukemia cell line)IT Antibiotics(antitumor;manuf.of antibi
41、otic K93-0711-R4 and K93-0711-R6 with Streptomyces sp.for inhibition of adriamycin-resistant P388 leukemia cell line)IT Antitumor agents(leukemia;manuf.of antibiotic K93-0711-R4 and K93-0711-R6 with Streptomyces sp.for inhibition of adriamycin-resistant P388 leukemia cell line)HOW MANY MORE ANSWERS
42、DO YOU WISH TO SCAN?(1):0,第五步:调整检索策略,评估新的检索结果:,50,第六步:显示结果,运用DISPLAY指令显示结果详细信息 当使用DISPLAY的时候，需要输入三部分信息：答案集L号码 答案数 格式,51,第六步:显示结果,52,第六步:显示结果,默认情况下，CAplus中的答案集是按照时间顺序从最新到最早排列的,=D L6 1,808 IBIB ABSL6 ANSWER 1 OF 808 CAPLUS COPYRIGHT 2006 ACS on STN ACCESSION NUMBER:2006:910077 CAPLUSTITLE:Study on mec
43、hanisms of action of enediyne antitumor antibiotic lidamycinAUTHOR(S):Gao,Rui-juan;Li,Dian-dong;Zhen,Yong-suCORPORATE SOURCE:Institute of Medicinal Biotechnology,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing,100050,Peop.Rep.ChinaSOURCE:Zhongguo Xinyao Zazhi(2006),15(13),10
44、39-1043 CODEN:ZXZHA6;ISSN:1003-3734PUBLISHER:Zhongguo Xinyao Zazhi Youxian GongsiDOCUMENT TYPE:JournalLANGUAGE:ChineseAB Lidamycin(LDM),one of nine-ring enediyne antitumor antibiotics,was isolated by spermatogonial assay from the metabolic products of Streptomyces globisporus C-1027,which was(下页继续),
45、53,第六步：显示结果,L6 ANSWER 808 OF 808 CAPLUS COPYRIGHT 2006 ACS on STN ACCESSION NUMBER:1953:68136 CAPLUSDOCUMENT NUMBER:47:68136ORIGINAL REFERENCE NO.:47:11551g-hTITLE:A review on the mechanism of action of certain temporary anticancer agentsAUTHOR(S):Skipper,Howard E.CORPORATE SOURCE:Southern Research
46、Inst.,Birmingham,ALSOURCE:Cancer Research(1953),13,545-51 CODEN:CNREA8;ISSN:0008-5472DOCUMENT TYPE:JournalLANGUAGE:UnavailableAB A review on the possible sites of biochem.action of temporary anticancer agents,e.g.,4-aminopteroylglutamic acids,urethan,formamide,2,6-diaminopurine,8-azaguanine,2,4-diam
47、inopyrimidines,A-methopterin,netropsin(an antibiotic from Streptomyces netropsis),N mustard,cortisone,and x-radiation.52 references,54,总 结,55,总 结,56,练习地目的在于帮助熟悉这些基本指令FILEEXPANDSEARCHD SCAN D SCAN HITDISPLAYLOG OFF,练 习,57,练 习,练习题1：Grape seed extract(GSE)have been reported to have several health benef
48、its,including treating heart diseases such as high blood pressure and high cholesterol.Recent publications have shown that in addition to heart related diseases,grape seed extract can also be used to treat cancer.These benefits may be due to the presence of proanthocyanidins found in grape seed extract.Find information on how grape seed extract or proanthocyanidins can be used to treat cancer.练习题2：检索“drugs for the treatment of AIDS”.,58,谢 谢！,
