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1、,肠道胆固醇吸收的心血管病风险,提纲1胆固醇代谢(肝脏和肠道)2胆固醇吸收与心血管病风险3怎样区分患者的胆固醇代谢类型,胆固醇代谢(肝脏和肠道),肝脏与肠道是胆固醇平衡最主要的两个器官胆固醇体内平衡是由一系列因素决定的:胆固醇合成食物摄入胆固醇吸收胆固醇排泄Dietschy JIM et al. JLipid Res. 1993: 34: 1637,肝脏在胆固醇体内平衡中的作用,胆固醇在肝脏内合成IntestineLiverPeripheralcetyl COATissuesCholesterol3 CHa-COO AcetateOOC-CH2-C-CHz-CHy-OHActivated is
2、opreneAtheromaShepherd J. Eur Heart J Supp/ 2001: 3: E2. Buhaescu I, Izzedine H. Clin Biochem. 2007: 40(9-10): 575,肝脏向循环系统中分泌Apo B100 Lipoproteins(VLDL)ntestineLiverPeripheralTissuesCholesterolApo B100Atheroma,oB1 Lipoproteins向循环系统中运输甘油三酯,胆固醇,胆固醇ntestineLiverPeripheralApo B10AtheromaGoldstein JL, Br
3、own MS, Science. 2001Shepherd J. Eur Heart Suppl. 2001: 3: E2,肝脏可以通过LDL受体清除Apo B100 LipoproteinsIntestineLiverPeripheralTissuesCholesterolLDLRBloodhermaal. J Clin invest. 1983: 71: 950: Goldstein6. J Biol Chem. 1974: 249 (16): 5153. Brown MSProc Nat/ Acad Sci. 1974: 71: 788: Goldstein JL, Brown MS. Science. 2001: 292: 1310. Rudling et alProc Nat/ Acad Sci. 1990: 87: 3469,LDL-C占循环中胆固醇的2/3,LDLC可以穿透动脉内皮ntestineLiverPeripheralTissuesCholesterolApo B100Atheroma1990: 87: 3469.; Simionescu et al. Ann NY Acad Sci. 1990: 598: 1.; Yu, Cooper. Front Biosc. 2001: 6: d332,
