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1、,2016年,Brief Introduction and etiopathogenesis(发病机理),01,02,03,CONTENT,Clinical symptoms(临床症状）,The latest research progress,Treatment and prevention of lupus erythematosus,LE,6年,04,1,Brief Introduction and etiopathogenesis(发病机理),1,Brief Introduction,Autoimmune disease(AID)Damage multiple systems with
2、 multiple organs involvedComplex clinical manifestationsLong durationSkin manifestationsThe majority of the patients are female.,2,3,4,1,5,Pathology（病理）,Pathological morphology varies depending on the condition,location,large changes.There are several common types.,Vascular lesions form of necrotizi
3、ng vasculitis of small vessels,including small arteries or arterioles.,Patients with kidney disease will also have diaease of the renal glomerulus and renal tubules and interstitial and blood vessels.,Cardiac abnormalities including pericarditis,myocarditis,heart valves and endocardial disease.,Path
4、ological changes of skin including epidermal（表皮的）atrophy（萎缩）,necrosis（坏死）of the skin ulcers（溃疡）and edema（水肿）.,Diffuse lesions(弥漫性病变)of the nervous system consist of fewer nerve cells,small vessel vasculitis,small infarction（梗塞）,necrosis and hemorrhage（出血）.,Pathogeny（病因）,The exact cause of Lupus Eryt
5、hematosus has not been found,which is the same as other autoimmune diseases.Environmental pollution can also cause this diaease which should be pay attention to.,Genetic factors,Infection factors,Endocrine factors,Environmental factors,Other factors,2,Clinical symptoms and detection methods,clinical
6、 symptoms,3,6,4,Raynauds phenomenon(雷诺现象）,Dermal pathology（皮肤病理）,5,1,9,2,Blood disorder(血液病变）,Organ damage,Lymphatic system,Fever,8,7,Arthritis(关节炎）,Oral or nasal pharyngeal ulcer,Infection（传染性）,clinical symptoms,01,Dermal pathology皮肤病理,Facial butterfly erythema（面部蝶形红斑）；disc erythema（盘形红斑）；dermatiti
7、s cause hair loss,Renault phenomenon is a loop around the disease.Under the stimulation such as cold or emotional tension,suddenly occurred in refers to small artery spasm.,Raynauds phenomenon(雷诺现象）,Blood disorder(血液病变）,All kinds of blood cells are reducing,additionnally,patients may suffer from vas
8、culitis,04,Organ damage,Patients may suffer from heart damage,lung damage,brain damage,gastrointestinal damage（消化道损害）,with lupus nephritis（狼疮性肾炎）and eye lesions,clinical symptoms,05,Lymphatic system,About 50%of SLE patients with local or systemic lymph node enlargement,in neck,armpits,jaws swelling，
9、which are soft and no tenderness.,Patients tend to be immunologic dysfunction,whose body can produce many kinds of substances,as a heat source and make the body heat.,Fever,Arthritis(关节炎）,08,Oral or nasal pharyngeal ulcer(口腔及鼻咽部溃疡）,clinical symptoms,9,Infection（传染性）？,Although the incidence of sle is
10、 far higher in our country than western countries,comparing with other common diseases is very rare.Because the patient is relatively small,a lot of people dont know much about this disease.when they see this disease,they will want to know whether it is infectious？The answer is no,sle will not sprea
11、d by one person to another person.There are many factors occurring to reduce the bodys immune tolerance,making the bodys immune function disorder.Patients with the disease in the plateau can work,study,and participate in the activities of society like the normal,3,Treatment and prevention of lupus e
12、rythematosus,LE,Treament,SLE系统性红斑狼疮,CLE,n,皮肤型红斑狼疮,红蝴蝶疮,In principle,CLE does not use hormones（激素）anti malaria drugs as the first choice.,Those who has light symptom-only mild rash,arthritis,pleurisy,dont need hormene,CorticosteroidsCTLImmunoadsorption therapy,1.Hormone therapy,.,2.The psychological
13、therapy of SLEThe therapy includes“revisiting”-help them lessen the intensity of emotion,prevention,.,1Removal of possible incentivesuse medicine of SLE prudently；Avoid exposing to sun chronically（use anti light agent）2 Keep optimistic3contraception（节育）If the patient have conceived,she had better do
14、 the treatment of abortion4 early diagnosis,4,The latest research progress,.,1.Artemisinin can treat lupus(SLE),SM934（水溶性青蒿素衍生物）is proved to be able to treat SLE,2.classification of CLE and the diagnosedirect immunofluorescence and photoprovocation may be applied to confirm the diagnosis in specific cases.A revised scoring system,the Cutaneous Lupus Erythematosus Disease Area and Severity Index(RCLASI)has recently been validated to assess disease activity and damage in CLE.,2016年,part1:张敬鸣part2：钱磊part3：宋天佳,THANK YOU,
