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1、肺结节CT随访策略,复旦大学附属华山医院放射科张家文,Case 1,女,66岁pGGN,Case 2,Case 3,肺结节(pulmonary nodule),定义:指肺实质内单发或多发的圆形或类圆形、直径3 cm,不伴有肺不张、无淋巴结肿大或肺内其他异常的病变,分类,纯磨玻璃密度(pGGN,pGGO)混合性结节(partial solid GGN)实性结节(Solid Nodule),实性结节无肺癌危险因素,排除吸烟史;年龄60岁;有肺癌史或肺外其他癌病史 4mm,无须随访,但患者必须完全知情随访的利与弊4 mm-6 mm,隔12个月随访1次,若无变化无需随访6 mm-8 mm,612、18
2、24个月各随访1次,无变化者可停止随访,实性结节具有1项肺癌危险因素,4 mm,隔12个月随访1次,若无变化无需随访4 mm-6 mm的结节,612、1824个月各随访1次,无变化的可停止随访6 mm-8 mm的结节,36、912个月各随访1次,若无变化在24个月再随访1次,无变化可停止随访,8mm实性结节随访,36、912、1224个月各随访1次,无变化可停止随访如果有恶性可能证据,建议活检或外科手术,pGGN 随访,5mm,单发,无须随访;(可能为AAH)5mm,多发,吸烟或其它肺癌危险因素,至少隔12个月随访1次5mm,3个月随访1次,无变化者可每年随访一次,至少3-5年pGGN增大或演
3、变实性结节,常常恶性结节,需立即进一步评估或手术切除 10mm,3个月随访1次,病灶仍然存在,外科切除或活检,部分实性结节随访,单发:8 mm,3,12,24个月各随访一次,然后每年随访一次,至少1-3年部分实性结节演变成实性结节或增长,常常恶性结节,需手术切除单发:8mm,3个月随访,接着PET-CT,外科活检单发:15mm,直接PET-CT、活检或外科切除多发:3个月随访,长期低剂量CT监测,结节大小与良恶性关系,3 mm,0.2%恶性 47 mm,0.9%恶性820 mm,18%恶性20 mm,50%恶性,推荐CT扫描技术,高分辨低剂量(80mA)薄层(2.5mm),良性结节,男,39岁
4、;a-GGN,b-3个月后随访,肺腺癌,女,59岁;a-GGN,b-5个月后随访,c-9个月后随访;有卵巢癌病史。,肺癌新分类与CT特征相关性,不典型腺瘤样增生(AAH),5mmpGGN腺癌中57%伴有AAH,女,57岁;右中肺AAH,肺门旁为腺癌。,原位癌(AIS),pGGNpart-solid GGN实性结节:很少PET假阴性,微浸润腺癌Minimally invasive adenocarcinoma(MIA),女,60岁,鳞状细胞腺癌(LPA),5mm部分实性结节:71%实性结节pGGN:7%,腺癌,女,66岁(a)pGGN(b)2 年后 随访(c)CT引导楔形切除,粘液腺癌(Inva
5、sive mucinous adenocarcinomas),实性结节实性为主结节分叶多发(BAC),CASE,女,57岁AISA:CTB:18月后C:PET(-),CASE,男,66岁A:左肺上叶pGGNB:2年后随访CT病理:鳞状上皮腺癌,CASE,女,70岁鳞状上皮腺癌图示每年一次随访,平均倍增时间,pGGN:813天部分实性结节:457天实性结节:149天,参考文献,CHEST 2013;143(5)(Suppl):e93Se120S Diagnosis and Management of Lung Cancer,3rd ed:American College of Chest Phy
6、sicians Evidence-Based Clinical Practice GuidelinesCurr Opin Pulm Med 2012,18:304312Guidelines for Management of Small Pulmonary Nodules Detected on CT Scans:A Statement from the Fleischner Society(The American College of Chest Physicians,ACCP),2005,谢 谢!,非实性结节随访策略,纯磨玻璃密度(pure ground-glass nodules,pG
7、GNs)混合性结节(part-solid GGNs)The rate of malignancy in subsolid nodules(SSNs)is higher than in solid nodules.There is close but imperfect correlation between the computed tomography(CT)features of SSNs and the spectrum of lung adenocarcinoma.In the presence of extrapulmonary malignancy,SSNs are more li
8、kely to represent a primary lung malignancy rather than metastatic disease.Serial CT imaging has shown stepwise progression in a subset of SSNs,characterized by increase in size and density of pure ground-glass nodules and development of solid component,the latter usually indicating invasive adenocarcinoma.The percentage of ground-glass attenuation in SSNs on CT correspond to the percentage of lepidic pattern on histology and is directely related to the prognosis.,